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Left Ventricular Assist Device clinical trials

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NCT ID: NCT05916612 Withdrawn - Clinical trials for Heart Failure With Reduced Ejection Fraction

Influence of Right Ventricular Function on Changes in Exercise Capacity After LVAD

Start date: July 2018
Phase:
Study type: Observational

This is an exploratory project with the purpose to describe the responses of the right ventricle (RV) and gas exchange during exercise in patients scheduled to undergo left ventricular assist device (LVAD) implant. Such information might be used to predict the likelihood of RV failure after LVAD implant. Additionally, although patients that undergo LVAD implantation have improved quality of life and survival, their exercise tolerance (although improved) remains markedly reduced compared to healthy subjects. No studies have used cardiopulmonary stress testing and echocardiography to assess cardiac function and gas exchange with LVAD implantation to determine potential factors responsible for their limited function. The aims of this study are as follows: 1. To assess the impact of right ventricle (RV) dysfunction on functional capacity before and after left ventricular assist device (LVAD) implant 2. To determine if the combined use of preoperative clinical, CPX and echo data can assist in predicting who will meet target improvements in functional capacity after LVAD implant.

NCT ID: NCT05063006 Completed - Clinical trials for Left Ventricular Assist Device

Exercise Tolerance in Patients With Implanted Left Ventricular Assist Device

Start date: February 15, 2017
Phase: N/A
Study type: Interventional

To evaluate the concept of dynamic pump speed optimization based on the echocardiographic assessment of aortic valve opening during cardiopulmonary exercise test.

NCT ID: NCT04423562 Recruiting - Prognosis Clinical Trials

PROgnostic Value of Exercise Capacity Measured as Peak Oxygen Uptake (pVO2) in Recipients of Left Ventricular Assist Devices

PRO-VAD
Start date: April 10, 2020
Phase:
Study type: Observational

Pooling of earlier VO2-studies conducted at the dept. of cardiology, Rigshospitalet, Denmark, and all LVAD centres of the World that wish to participate. The purpose is to investigate the prognostic value of VO2 in recipients of durable LVADs using data from studies already conducted.

NCT ID: NCT04377854 Recruiting - Heart Failure Clinical Trials

Prognostic Value of BNP in MCS - a 25 Year Follow up Study

Start date: September 18, 2020
Phase:
Study type: Observational [Patient Registry]

A biobank has been created to investigate the prognostic value of biomarkers (mainly BNP) in patients implanted with durable mechanical assist devices comparing patients with advanced HF supported by MCS with those who are transplanted and those who remain on optimal medical therapy. Patients will be followed up for 25 years after inclusion.

NCT ID: NCT04264182 Terminated - Clinical trials for Heart Failure, Systolic

STandardized Ultra-conservative Or Physician-directed ICD Programming for Continuous Flow LVAD Support

Start date: February 3, 2020
Phase: N/A
Study type: Interventional

This study will evaluate the utilization of an ultra-conservative programming strategy to reduce shocks for ventricular arrhythmias (VA) among patients with heart failure, an implantable cardioverter-defibrillator (ICD) and continuous flow (CF) left ventricular assist device (LVAD). Patients on LVAD support demonstrate unique hemodynamic tolerability of VA, and the role for ICDs among patients with newer generation CF LVADs remains less clear than the older generation devices. Prior studies have explored extended detection ICD programming to reduce unecessary or potentially avoidable shocks to patients. However, no prospective randomized study to-date has evaluated such programming strategies in the CF LVAD patient population. The study hypothesis is that ultra-conservative (UC) ICD programming will result in a reduction of shocks and an improvement in quality of life without increasing hospitalizations, syncope or death among patients on CF LVAD support, and the primary design is a 1:1 randomization between UC programming over standard, physician discretion programming.

NCT ID: NCT04205760 Recruiting - Cardiac Surgery Clinical Trials

Preoperative Nutritional Optimization and Physical Exercise for Patients Scheduled for Elective Implantation for a Left-Ventricular Assist Device

PROPER-LVAD
Start date: January 2, 2022
Phase: Phase 3
Study type: Interventional

This is a pilot, randomized, multicenter interventional trial of a combined preoperative oral nutritional support (ONS) and physical exercise therapy in patients planned for elective implantation of a left-ventricular assist device (LVAD). This pilot study pursues to demonstrate the feasibility and safety of a study protocol to optimize the patients' nutritional and physical state to reduce the number of postoperative complications and consequently to ameliorate the patients' outcome.

NCT ID: NCT03636815 Completed - Physical Therapy Clinical Trials

The Effect of Physical Therapy Intervention in Patients With Left Ventricular Assistive Device on Physical Function

LVAD
Start date: April 8, 2018
Phase:
Study type: Observational

To retrospectively investigate the effect of physical therapy intervention on improving physical function of patients post left ventricular assist device (LVAD) through electronic medical record survey

NCT ID: NCT03583970 Recruiting - Heart Failure Clinical Trials

Veno-arterial Extracorporeal Membrane Oxygenation Prior to Left Ventricular Assist Device Implantation.

LVAD-ECMO
Start date: July 5, 2018
Phase:
Study type: Observational

Cardiogenic shock is an uncommun pathology with a high mortatily rate around 45%. Veno arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary extracorporeal assist device which restore an adequate blood flow when a circulatory failure occures. VA-ECMO main indication is refractory cardiogenic shock whatever the etiology. Current medical care of terminal cardiac failure includes use of long-term mechanical circulatory support devices (MCSD) such as Left Ventricular Assist Device (LVAD). LVAD therapy may lead to heart transplant (bridge to transplantation), to recovery (bridge to recovery) or to permanent implantation (destination therapy). Few patients with refractory cardiogenic shock treated with VA-ECMO may secondarily need a long term MCSD with LVAD. LVAD long-term heart assist showed interesting survival rate when implantation occured (71% after 2 years follow-up and 45% after 4 years follow-up) out of acute heart failure situation. There are only few datas concerning LVAD implantion during refractory cardiogenic shock, with a mortality between 20 to 50% in different studies. In this way, in comparaison of current few datas on the subject of LVAD implantation under VA-ECMO, the investigators (15 french-speacking centers) would retrospectively describe a large population.

NCT ID: NCT03458988 Completed - Clinical trials for Left Ventricular Assist Device

Blood-pressure Measuring in Patients Carrying a Left Ventricular Assist Device

LVAD
Start date: February 27, 2018
Phase: N/A
Study type: Interventional

To prove the novel device is able to reliably detect pulsatility in patients with CF-VADs and to analyze whether pre-programmed intrinsic pulsatility of the 3rd generation CF-VADs can also be picked up. The study is not designed to measure blood pressure. Should this pilot study be successful in detecting enough pulsatility a follow-up study would then try to transfer the results into blood-pressure values with the help of comparators in order to identify an easier and more reliable method to measure BP in CF-VAD patients. .

NCT ID: NCT03346278 Terminated - Clinical trials for Myocardial Infarction

Text Message Intervention to Improve Cardiac Rehab Participation

Start date: November 7, 2017
Phase: N/A
Study type: Interventional

Cardiac rehabilitation (CR) is strongly recommended for patients with coronary heart disease. However, patient enrollment and completion of cardiac rehabilitation is low. This study will examine if a mobile phone intervention that uses a text messaging program can successfully promote participation in cardiac rehabilitation.