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Clinical Trial Summary

- Intra-abdominal pressure(IAP) is defined as a steady state pressure of the abdominal cavity

- many studies have proved IAP as a prognostic factor that elevated IAP influences hemodynamics and multiple organs dysfunction

- In previous studies, most of them was based on the septic patients of medical diseases. And it is rare about sepsis of surgical diseases such as traumatized or postoperative patients

- We hypothesized that intra-abdominal hypertension may affect clinical course such as length of stay of intensive care unit, weaning of mechanical ventilation, proceeding of enteral feeding and mortality

- Our study was aimed to investigate prevalence of IAH and risk factors and to analyze clinical course and prognosis influenced by IAH in surgical patients with severe sepsis


Clinical Trial Description

- Inclusion criteria older than 18 diagnosed as severe sepsis agreed on informed consent

- Exclusion criteria refused to participate in the study traumatic injuries on urethra or bladder open abdomen status

- Definition of severe sepsis organ failure more than one organ with sepsis arterial blood lactate concentration of at least 4mmol/L hypotension with a systolic blood pressure lower than 90mmHg

- Definition of intra-abdominal hypertension intra-abdominal pressure more than 12mmHg

- Measurement of IAP measuring via three lument urinary catheter measuring after filling with 25ml normal saline measuring in supine position at level of mid-axillary line on iliac crest measuring three times a day during ICU stay ;


Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


NCT number NCT01784458
Study type Observational [Patient Registry]
Source University of Ulsan
Contact
Status Completed
Phase N/A
Start date March 2009
Completion date October 2009

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