Clinical Trials Logo

Laryngostenosis clinical trials

View clinical trials related to Laryngostenosis.

Filter by:

NCT ID: NCT06275269 Not yet recruiting - Subglottic Stenosis Clinical Trials

Endoscopic Mucosal Injection Versus Ultrasound-Guided Injection of Triamcinolone to Treat Subglottic Stenosis

Start date: March 10, 2024
Phase: N/A
Study type: Interventional

This study employs a multicenter, randomized controlled trial method, where patients meeting the inclusion criteria for subglottic stenosis are randomly divided into two groups. These groups are respectively undergoing translaryngeal endoscopic mucosal injection and ultrasound-guided injection of triamcinolone treatment. The comparison will focus on various indicators such as therapeutic effect, incidence of adverse reactions, treatment costs, and hospital resource utilization between the two groups. The safety and effectiveness will be compared to determine the relative merits of the two treatment methods.

NCT ID: NCT06183515 Completed - Clinical trials for Airway Complication of Anesthesia

Continuous Positive Airway Pressure (CPAP) Pediatric Patients With Subglottic Stenosis Who Undergo Balloon Dilatation

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

Nasal continuous positive airway pressure (CPAP) acts as a 'pressure' bridge between spontaneous breathing and controlled mechanical ventilation. As a result, there is an increasing trend in the prophylactic use of nasal CPAP in pediatric patients following high-risk airway procedures to reduce postoperative airway complications. Still, there is no study published on the prophylactic use of balloon dilatation in children with tracheal stenosis.The study hypothesizes that implementing postoperative prophylactic CPAP in pediatric cases with subglottic stenosis undergoing balloon dilation may shorten recovery time and minimize airway complications.

NCT ID: NCT05688488 Recruiting - Glottic Carcinoma Clinical Trials

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

Start date: May 5, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.

NCT ID: NCT05535803 Enrolling by invitation - Tracheal Stenosis Clinical Trials

Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells

Start date: June 1, 2021
Phase: Phase 2
Study type: Interventional

The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

NCT ID: NCT05309616 Not yet recruiting - Clinical trials for Idiopathic Subglottic Stenosis

Effects of Interleukin (IL)-17A Inhibition on Idiopathic Subglottic Stenosis

Start date: September 2024
Phase: Phase 2
Study type: Interventional

The purpose of this phase 2 study is to examine if inhibiting IL-17A activation using the biologic drug Taltz, in idiopathic subglottic stenosis patients will decrease scar fibroblast proliferation therefore reducing or eliminating the need for invasive or repeat surgeries.

NCT ID: NCT04734483 Recruiting - Larynx Disease Clinical Trials

The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.

NCT ID: NCT03130374 Completed - Clinical trials for Mesenchymal Stem Cells

Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells

Start date: January 3, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

NCT ID: NCT01977911 Withdrawn - Tracheal Stenosis Clinical Trials

Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants

RegenVOX
Start date: April 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to test a new groundbreaking treatment for narrowing of the voicebox and upper windpipe, which can be due to injury, inflammatory disease or cancer treatment. Narrowing of the voicebox or upper windpipe can leave patients dependant on a tracheostomy tube to breath through (a tube or hole in the neck), which can require a high level of care with regular hospital visits and can lead to recurrent chest infections. Regular surgical procedures may be necessary to widen the airway. Speaking may be very difficult or not even possible, breathing is usually a struggle and swallowing can also be affected. Patients feel very tired all the time. The new treatment tested by this study is an implant that will partially replace the voicebox or upper windpipe in order to cure the narrowing. The implant is based on a human donor voicebox or windpipe that has been processed with detergents and enzymes in order to remove all the cells from the donor, leaving a 'scaffold' of connective tissue. The patient's own stem cells are removed from the bone marrow, then are grown on the scaffold in the laboratory. These cells will form the cartilage in the wall of the scaffold. A split skin graft from the patient may be needed to line the inside of the implant. The implant can be considered 'living' due to the cells grown on it, and this type of treatment is referred to as 'tissue engineering' or 'regenerative medicine'. Once these cells have attached and started to grow on the scaffold, it is ready to be implanted into the patient, and an operation is performed which occurs in two separate stages. The final stage of the operation involves removing the narrow section of voicebox or upper windpipe and implanting the scaffold to reconstruct it. Patients will be followed up for two years after this operation, with investigations such as CT scans, examination of the voicebox and windpipe with a flexible camera (bronchoscopy) and blood tests performed at specific times. It is intended that this treatment will significantly improve patients' symptoms resulting in better breathing, swallowing and voice function, reducing the need for repeated hospital visits and procedures and enhancing patients' quality of life.

NCT ID: NCT01690078 Completed - Micrognathia Clinical Trials

Functional Modeling of the Pediatric Airway

Start date: April 2011
Phase: N/A
Study type: Observational

The investigators hypothesize that a functional computational model that simulates the mechanical and aerodynamic behavior of the upper airway in children with Pierre Robin Sequence (PRS) and laryngeal lesions (e.g. subglottic stenosis or SGS) can be used as an effective diagnostic and treatment planning tool.

NCT ID: NCT01523275 Terminated - Tracheal Stenosis Clinical Trials

Study of Mitomycin-C Application in Laryngotracheal Stenosis

Start date: August 2012
Phase: N/A
Study type: Interventional

This is a randomized, prospective, double-blind, placebo-controlled clinical trial of the use of mitomycin-C topical application as an adjunctive treatment in the endoscopic surgical treatment of patients with laryngotracheal stenosis. We hypothesize that the use of mitomycin-C improves patient outcome in the endoscopic surgical treatment of laryngotracheal stenosis.