Nitroglycerin Infusion During Cardiac Surgery

Status Completed

Clinical Trial Summary

Hypothermic cardiopulmonary bypass results in peripheral vasoconstriction and heparin trapping. Hypoperfusion and ischemic-reperfusion injury are associated with systemic inflammatory response, while insufficient and delayed neutralization of heparin by protamine may contribute to more blood loss during rewarming stage. Nitroglycerin infusion, an NO-related vasodilator, is an established and effective treatment for unstable angina, myocardial infarction, congestive heart failure, and perioperative hemodynamic management for cardiac surgery. Therefore, we hypothesize that nitroglycerin infusion during rewarming corrects systemic ischemic stress and facilitates heparin neutralization in cardiac surgery.

Clinical Trial Description

A randomized clinical trial in a tertiary academic center in patients with cardiac surgery, to receive either nitroglycerin infusion dose of 0-0.1 mcg/kg/min, or 1-5 mcg/kg/min during rewarming in cardiopulmonary bypass. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01901419
Study type	Interventional
Source	Tri-Service General Hospital
Contact
Status	Completed
Phase	N/A
Start date	July 8, 2013
Completion date	June 8, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04854603` - Dairy Products With Reduced Sugar and Blood Glucose	N/A
Not yet recruiting	`NCT05004558` - Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias	N/A
Not yet recruiting	`NCT04018430` - Impact of Oral Glucose Tolerance Test on Extent of Hemoglobin Glycation
Completed	`NCT03763240` - BSE on Blood Glucose	N/A
Completed	`NCT05504096` - Calibration and Evaluation of Non-Invasive Wireless Blood Glucose Monitoring	N/A
Completed	`NCT03686293` - A Personal Microbiome-dependent Glucose Response in Healthy Young Volunteers	N/A
Completed	`NCT05400694` - Functional and Value-Added Dairy Products and Blood Glucose Control	N/A
Terminated	`NCT03455985` - Effectiveness of a Diabetes Focused Discharge Order Set Among Poorly Controlled Hospitalized Patients Transitioning to Glargine U300 Insulin	N/A
Completed	`NCT05163587` - Composite Flour and Its Antdiabetic Potential	N/A
Completed	`NCT03469869` - Effects of Balanced and Sustainable Diet Application for Insulin Resistance and Inflammation Marker of Obese People	N/A
Completed	`NCT04961086` - Health Effect of Energy Drink Consumption	N/A
Completed	`NCT04373863` - Assessment of Lifestyle, Blood Pressure, Cholesterol and Glycated Hemoglobin in a Specific Population
Active, not recruiting	`NCT04827615` - Evaluation of the Ambuja Cement Foundation Noncommunicable Disease Program in Bathinda District of Punjab, India	N/A
Completed	`NCT04850326` - Clinical Study to Evaluate the Short Time Efficacy of AP Green Tea Extract Affer High Fat, High Carbohydrate Diet	N/A
Recruiting	`NCT04755062` - A Culturally-relevant Micronutrient-dense Plant-rich (mNDPR) Dietary Intervention for Native Americans	N/A
Not yet recruiting	`NCT04100369` - Admission Blood Glucose as a Predictor of Morbidity and Mortality in Polytraumatized Patients
Completed	`NCT03412617` - Diets, Metabolic Profile and Gut Microbiota Among Indonesian Women in Minangkabau and Sundanese-ethnic Community	N/A
Completed	`NCT05222659` - Perioperative Glucose and Insulin Changes in Major Urologic Surgeries
Completed	`NCT04342624` - Investigation of Cinnamon Spice on Glucose Tolerance in Subjects With Pre-diabetes	N/A
Completed	`NCT04446754` - The Genetic Effects of rs7903146 and Dietary Intake on Type 2 Diabetes Mellitus Risk in a Healthy Population