Knee Clinical Trial
— MR7T-KneeTraumOfficial title:
Exploration of Knee Injuries Using 3 Tesla and 7 Tesla Magnetic Resonance Imaging at the University Hospital of Poitiers.
Verified date | March 2024 |
Source | Poitiers University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The knee is the most stressed and exposed joint in sports practice (70 to 85% of Anterior Cruciate Ligament ruptures occur during sports activities). Although traumatic knee injuries are already described in radiology and 1.5 Tesla and 3 Tesla MRI, there are cases of post-traumatic knee pain with a normal MRI (with a risk of underestimating a traumatic injury that may worsen without appropriate treatment) and cases of "ambiguous" MRI findings (uncertainty between low or high-grade ligament or meniscal injury, presence or absence of meniscal attachments, complete versus partial rupture of the Anterior Cruciate Ligament, associated cartilage lesion versus intact cartilage), which directly impact orthopedic or surgical therapeutic management.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | December 15, 2025 |
Est. primary completion date | December 15, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: - Age = 18 and < 60 years - Knee injury less than 2 months old - Patients who have undergone or will undergo a 3T MRI - Subject with no contraindication to MRI (metallic splinter, pacemaker, …) - Free subject, without guardianship or curatorship or subordination - Patient benefiting from a Social Security plan or benefiting from it through a third through a third party - Informed consent signed by the patient after clear and fair information on the study Exclusion Criteria: - Subjects with contraindications to 7T MRI (pregnancy, metallic fragments, pacemakers, copper intrauterine devices, tattoos larger than 5 cm in examination area, stents, coils, ocular metallic foreign bodies (accidental or otherwise), cochlear implants, and generally any electronically implanted medical device; metallic heart valves, previously implanted vascular clips on a cranial aneurysm) - History of knee surgery. - Patient without Social Security coverage or coverage through a third party. - Patient suffering from claustrophobia. - Individuals benefiting from enhanced protection, namely minors, persons deprived of liberty by a judicial or administrative decision, adults under legal protection, and emergency patients. - Pregnant or breastfeeding women, women of childbearing age without effective contraception (hormonal/mechanical: oral, injectable, transdermal, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy). |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Poitiers University Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Describe and quantify post-traumatic injuries of the ligaments (Anterior Cruciate Ligament, Posterior Cruciate Ligament, Lateral Collateral Ligament, Medial Collateral Ligament) using 7T MRI compared to 3T MRI in cases of post-traumatic knee pain. | For the Anterior Cruciate Ligament (ACL) and Posterior Cruciate Ligament (PCL), they will be described and classified as follows: no abnormality, complete rupture, or partial rupture depending on the location (proximal, medial, distal). For the Lateral Collateral Ligament (LCL) and Medial Collateral Ligament (MCL), the ligament classification will be applied (3 grades). | 27 to 30 months | |
Secondary | Describe and quantify post-traumatic meniscal injuries using 7T MRI compared to 3T MRI in cases of post-traumatic knee pain. | For the menisci, the classification of Israkes, Trillat, Arnoczky, and Warren will be applied. | 27 to 30 months | |
Secondary | Describe and quantify post-traumatic musculotendinous injuries using 7T MRI compared to 3T MRI in cases of post-traumatic knee pain. | For musculoskeletal injuries:
- 3 grades will be used: inflammatory, partial rupture, complete rupture. |
27 to 30 months | |
Secondary | Describe and quantify post-traumatic bone injuries using 7T MRI compared to 3T MRI in cases of post-traumatic knee pain. | For bone injuries:
- 3 grades will be used: bone edema, subchondral fissure, fracture. |
27 to 30 months | |
Secondary | Describe and quantify post-traumatic cartilage injuries using 7T MRI compared to 3T MRI in cases of post-traumatic knee pain. | For cartilage injuries, the Outerbridge classification will be applied. | 27 to 30 months | |
Secondary | Evaluate Cohen's Kappa coefficient value to quantify the inter-rater reliability with 3 and 7 Tesla MRI findings | The inter- and intra-observer study will be conducted by reviewing the images by different radiologists. This will allow us to quantify the variability by comparing the assessment criteria. | 27 to 30 months | |
Secondary | Evaluate Cohen's Kappa coefficient value to quantify the intra-rater reliability with 3 and 7 Tesla MRI findings | The inter- and intra-observer study will be conducted by reviewing the images by different radiologists. This will allow us to quantify the variability by comparing the assessment criteria. | 27 to 30 months | |
Secondary | Compare the 7T structural MRI findings of traumatic knee injuries to the structural findings of the surgical reports | For defining the semiotics, the MRI report at 7T will be compared to the surgical report, if applicable. The surgical report will be considered as the reference for the lesions identified by the surgeon (as arthroscopy is the gold standard examination). | 27 to 30 months |
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