Investigating the Effect of Dronabinol on Post-surgical Pain

Status Withdrawn

Clinical Trial Summary

This study is designed to investigate the effect of dronabinol on post operative pain in patients undergoing total knee replacement (for their own clinical care).

Clinical Trial Description

Total knee replacement is a common surgical procedure that restores function to the damaged joint. Recovery from this procedure takes weeks and requires opioids to manage post-surgical pain. The goal of this study is to investigate whether dronabinol (synthetic THC) can reduce pain and the need for opioid medication following this particular surgery. Subjects will be recruited from the Department of Orthopedic Surgery. All subjects will undergo total knee replacement as part of their clinical care (the surgery itself is not part of this study). The study begins following discharge from the hospital. They will be asked to take dronabinol or placebo as they recover from surgery. During this time they will be given their usual pain medications at discharge which includes opioids for pain. The opioids are to be taken if the subject is experiencing pain. The investigator's hypothesis is that subjects taking dronabinol will need fewer doses of opioids to control pain. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04099355
Study type	Interventional
Source	New York State Psychiatric Institute
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	September 1, 2025
Completion date	August 30, 2027

View Details

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