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Knee Replacement Surgery clinical trials

View clinical trials related to Knee Replacement Surgery.

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NCT ID: NCT06234631 Recruiting - Clinical trials for Osteoarthritis, Knee

Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

CORK
Start date: March 13, 2024
Phase: Phase 2
Study type: Interventional

The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery. The information collected in this study is necessary to help understand whether CBD may be a useful medication before and/or after surgery. The study hypothesis is that CBD exerts opioid-sparing effects through anti-inflammatory, analgesic, and anxiolytic mechanisms.

NCT ID: NCT05950646 Recruiting - Dexmedetomidine Clinical Trials

Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality

Start date: November 1, 2023
Phase: Phase 4
Study type: Interventional

Sleep disturbances are prevalent in older patients with osteoarthrosis or fracture who are scheduled for knee or hip replacement surgery. The occurrence of sleep disturbances is associated with worse outcomes including increased risk of delirium and cardiac events, and worsened functional recovery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, anxiolytic, and analgesic properties. It exerts sedative effects via activating the endogenous sleep pathways and produces a state like non-rapid eye movement sleep, which is different from opioid- and benzodiazepine-induced sedation. Esketamine is a N-methyl-D-aspartic acid receptor antagonist and has been used as an anesthetic and analgesic. Recent studies showed that low-dose esketamine has anti-depressive and sleep-promoting effects. The investigators suppose that mini-dose dexmedetomidine-esketamine combined infusion at night can improve perioperative sleep quality in patients scheduled for knee or hip replacement surgery.