Knee Injuries Clinical Trial
Official title:
Does Post-Operative Intra-Articular Platelet Rich Plasma Injection Improve Meniscal Repair Outcomes
The investigator's hypothesis was that intra-articular knee injection with PRP in patients underwent arthroscopic meniscal repair and didn't receive intra-surgical PRP, may add beneficial effect on post-meniscal repair outcomes regarding pain, functional state of the operated knee as well as healing process.
The study was done on 30 patients underwent arthroscopic isolated meniscal repairs performed
by a single surgeon but unfortunately didn't receive PRP injection during the repair
procedure.
Random, double blinded selection of 15 patients to constitute the PRP-group was injected
intra-articularly with about 5 ml of PRP in the operated knee joint. The other fifteen
patients were not injected and constituted control group. PRP preparation:
Thirty ml of venous blood was taken from every patient and collected in sodium citrated
sterile tubes. Platelet concentrates obtained by adjusting centrifuge at 1800 rpm for 15 min
to separate erythrocytes, then at 3500 rpm for 10 min to concentrate the platelets. The
preparation was done by a single laboratory technician. Thus 5 ml of PRP were obtained, 0.2
mL of 10% calcium chloride was added to the final product to activate the platelets and
injected immediately without storage. Procedure Pre-injection guidelines were given to all
patients (in PRP group) in the form of stopping steroidal and non-steroidal anti-inflammatory
drugs for at least one week before the procedure, as well as stopping any anticoagulant drugs
5 days before the procedure, increasing intake of fluids within the 24 hours prior to the
procedure and anti-anxiety medication were required for anxious patients. Injection, under
complete aseptic techniques, was performed while the patient was in supine position, and the
knee was fully extended, using the lateral approach. Patients were instructed after injection
to avoid using the injected leg for 24 hours, to use ice packs over the injected joint and
not to use NSAIDs for another one week.
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