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Knee Degenerative Disease clinical trials

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NCT ID: NCT01183728 Completed - Knee Osteoarthritis Clinical Trials

Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells

KDD&MSV
Start date: May 2010
Phase: Phase 1/Phase 2
Study type: Interventional

In this prospective study we aim to evaluate the feasibility and safety of the implantation of 40 millions MSV in knees with osteoarthritis of grade II-IV (Kellgren and Lawrence). The working hypothesis proposes that MSV antiinflammatory effect will help healing of articular cartilage degeneration to a grade enough to be objectivized by questionnaires and imaging procedures. The study of quantitative changes in structure and composition of cartilage determined by MRI T2-mapping (Cartigram ) will be performed at 6, 12 and 24 months. Pain and disability will be assessed by visual analogue scale (VAS), WOMAC, Lequesne Index and evaluation of the quality of life by Short Form 36 questionnaire (SF-36) completed at 3, 6,12 and 24 months.