The Use of Stromal Vascular Fraction for Knee Arthrosis

Knee Arthrosis Clinical Trial

Official title:

Gebruik Van Stromale Vasculaire Fractie Uit Vetweefsel na Invriezing Voor Knie Arthrose

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06171204
• Other study ID #: BC-07772
• Status: Recruiting
• Phase: N/A
• Start date: September 19, 2022
• Est. completion date: December 31, 2026

Study information

• Verified date: December 2023
• Source: University Hospital, Ghent
• Contact: Bernard Depypere, MD
• Phone: 093325730
• Email: bernard.depypere[@]ugent.be
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A trial to investigate the safety and efficacy of SVF for the treatment of knee arthrosis.

Patients will undergo a single liposuction to obtain the SVF. The SVF will then be isolated and frozen in our laboratory. The SVF will then be injected up to 2 times into the fat pad of the patient's knee.

Description:

Stromal Vascular Fraction (SVF) from adipose tissue is increasingly being used in the clinic for a variety of conditions (skin disorders, joint pain, etc.). SVF is a collective term for cells that can be obtained from liposuction fat. These cells can be separated from the fat by mechanical processing of the liposuction fat combined with an additional centrifugation.

Despite the fact that enough SVF can be isolated after such a liposuction for multiple treatments (>3), our research group has found a way to safely freeze SVF without significant loss of SVF cells. In this way, a patient would only have to undergo one liposuction and associated anesthesia to be able to obtain multiple SVF treatments.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 10
• Est. completion date: December 31, 2026
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• Legal capacity

• Osteochondral lesions

• Inflammatory complaints

• (Peri)tendinitis or tendinopathies and ligamentous injuries

• Impingement complaints

• Arthrofibrosis

• Anterior knee pain

Related Conditions & MeSH terms

• Joint Diseases
• Knee Arthrosis
• Osteoarthritis

Intervention

Procedure:
• Injection of SVF in fat pad of the knee
Knee fat pad injection with SVF at orthopaedics/physical medicine outpatient clinic

Locations

Country	Name	City	State
Belgium	UZ GENT	Gent	Oost-Vlaanderen

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Ghent

Country where clinical trial is conducted

Belgium, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluation of the safety of SVF injections after cryo preservation	The patient will complete the KOOS questionnaire (Knee Injury and Osteoarthritis Outcome Score) on several timepoints.	1 year