KIDNEY TRANSPLANTATION Clinical Trial
Official title:
An Open, Multicentre, Randomised, Parallel Group Study to Compare in Marginal Old-for-old Renal Transplant Patients the Safety and Efficacy of Two Treatments: Sequential Mycophenolate Mofetil/Delayed Tacrolimus Plus Steroids vs Tacrolimus Plus Mycophenolate Mofetil in Patients Requiring Induction With Anti-IL2 Antibody
The purpose of this study is to explore the safety and efficacy of two different immunosuppressive regimens (sequential tacrolimus/mycophenolate mofetil [MMF] plus steroids versus tacrolimus plus MMF, following induction with daclizumab) in recipients of marginal donor kidneys.
An open, multicentre, randomized, parallel group study to compare in marginal old-for-old
renal transplant patients the safety and efficacy of two treatments: sequential
mycophenolate mofetil/delayed tacrolimus plus steroids vs tacrolimus plus mycophenolate
mofetil, in patients requiring induction with anti-IL2 monoclonal antibody.
Elderly (≥50 years) low risk patients (PRA grade ≤50%, in the previous 6 months) receiving
an allograft transplantation of marginal kidney(s) from elderly (>65 years) donors
(old-for-old allocation) will be randomized to one of the following treatment arms:
Arm1: Sequential mycophenolate mofetil/tacrolimus/steroids
Arm2: Tacrolimus/mycophenolate mofetil/steroid one single dose (perioperatively)
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