Kidney Transplantation, Mannitol Clinical Trial
Official title:
Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation
In this study we want to evaluate the effect of mannitol on postoperative renal biomarkers in
patient receiving cadaveric renal transplantation. Furthermore we want to evaluate the effect
of mannitol on perioperative redox status in patients receiving renal transplantation using
the oxidation-reduction potentials assessed with the RedoxSYS®system.
We are planning to perform a double-blind randomized controlled trial. In the study, mannitol
20% with a dose of 1g / kg / BW (5 ml / kg / BW) will be compared to placebo with NaCl 0.9%
in the dose of 5 ml / kg / BW. Patients will be randomized to receive either the mannitol or
NaCl. The follow-up of the study is 24 hours. The following biomarkers will be determined
befor induction of anesthesia and 24 hours after administration of study medication: CCL2,
CHI3LI, GH, HGF, MMP1, MMP8, Tie2, TNF-R1, VCAM-1, KIM-1, Cystatin C, FGF23, IGFB7, NGAL and
IL 18.
Furthermore we want to perform sORP and cORP before induction of anesthesia, just before
bolus of mannitol, 5 min after bolus of mannitol and after operation in anesthetic recovery
room.
Data will be collected, compared and published at the end of the study. It is planned to
include a total of 34 patients in the study.
n/a