Clinical Trials Logo
  1. Home
  2. Other
  3. NCT04819880

Multicenter, Randomized, Open-Label Study to Evaluate AT-1501 in Patients Undergoing Kidney Transplant

Kidney Transplant Clinical Trial

Official title:
A Phase 2, Multicenter, Randomized, Open-Label Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of AT-1501 in Patients Undergoing Kidney Transplant

Clinical Trial Summary

This is a randomized, multicenter, open-label, active control, non-inferiority study to assess the safety and efficacy of AT-1501 compared with tacrolimus in the incidence of BPAR events through 6 months post-transplant.

Clinical Trial Description

This is a randomized, multicenter, open-label, active control, non-inferiority study to assess the safety and efficacy of AT-1501 compared with tacrolimus. Approximately 120 de novo kidney transplant recipients will receive rabbit anti-thymoglobulin (rATG) (Thymoglobulin®) induction, corticosteroid maintenance, mycophenolate, and will be randomized 1:1. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04819880
Study type Interventional
Source Eledon Pharmaceuticals
Contact Jennifer Areh
Phone 6175952605
Email jareh@eledon.com
Status Not yet recruiting
Phase Phase 2
Start date June 2021
Completion date March 30, 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT04087720 - Study of Pegloticase in Participants With Uncontrolled Gout Who Have Had a Kidney Transplant Phase 4
Completed NCT03749356 - Study to Evaluate the Efficacy and Safety of Once-Daily Tacrolimus in Kidney Transplant Recipients Phase 4
Withdrawn NCT05811468 - Study Correlation Between Blood, Tissue Gene Expression, Donor Derived Cell Free DNA and Histopathology in Kidney Transplant Recipients
Completed NCT03527238 - Optimizing Immunosuppression Drug Dosing Via Phenotypic Precision Medicine Phase 2
Completed NCT00498576 - Melatonin and Adiponectin in Hypertensive Kidney Transplant N/A
Completed NCT00642655 - Rituximab and Intravenous Immunoglobulin (IVIG) for Desensitization in Renal Transplantation Phase 1/Phase 2
Completed NCT00374400 - The Paired Donation Consortium Paired Donation Program N/A
Completed NCT01710033 - A Study Of CP-690,550 In Stable Kidney Transplant Patients Phase 1
Completed NCT00205257 - Prediction of Acute Rejection in Renal Transplant Phase 1
Completed NCT02711826 - Treg Therapy in Subclinical Inflammation in Kidney Transplantation Phase 1/Phase 2
Withdrawn NCT03978494 - Study to Compare Pharmacokinetics of Tacrolimus Prolonged-release (PR) Capsules and Advagraf® PR Capsules in Stable Kidney Transplant Patients. Phase 1
Completed NCT03837522 - Trial to Define the Benefits and Harms of Deceased Donor Kidney Procurement Biopsies N/A
Not yet recruiting NCT06025240 - Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
Completed NCT05029310 - Effects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant Recipients Phase 4
Completed NCT03644485 - Clinical Outcome of Delayed or Standard Prograf Together With Induction Therapy Followed by Conversion to Advagraf in Donation After Cardiac (or Circulatory) Death (DCD) Kidney Transplant Recipients Phase 4
Active, not recruiting NCT02409901 - Effects of Personalized Physical Rehabilitation in Kidney Transplant Recipients N/A
Completed NCT01047410 - ACtive Care After Transplantation, the ACT Study N/A
Completed NCT00940940 - Safety and Immunogenicity of Zostavax Vaccine in Patients Undergoing Living Donor Kidney Transplantation Phase 4
Completed NCT00217126 - The Study of Long-term Deterioration of Kidney Transplants. Phase 4
Completed NCT00270712 - A Study of Factors That Affect Long-Term Kidney Transplant Function