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A Study That Will Look at the Impact of Immunosuppression on Antibody Production in Kidney Transplant Recipients.

Kidney Transplant Clinical Trial

Official title:
The Effects of Thymoglobulin on Antibody Screening Cells.

Clinical Trial Summary

This study is being done to collect blood and bone marrow samples for biologic studies of antibody producing cells. Donor specific antibodies can cause damage to the kidneys after they are transplanted. The study will look at the impact of immunosuppression on antibody production by antibody producing cells.

Clinical Trial Description

Bone marrow and blood samples from both non-sensitized kidney transplant recipients and sensitized kidney transplant recipients will be collected. The samples will be used to compare the effect immunosuppression has on the antibody producing cells from both of these kinds of transplant recipients. Bone marrow will be collected from sensitized kidney transplant recipients before desensitization therapy prior to transplantation and at the time of kidney transplant surgery. Non-sensitized patients will have bone marrow collected only at the time of kidney transplant surgery. Blood will be collected at the same time point that the marrow is collected in both kinds of patients. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00275717
Study type Observational
Source Mayo Clinic
Contact
Status Completed
Phase Phase 1
Start date March 2005
Completion date December 2010
View Details
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