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Donor-derived Cell-free DNA for Early Diagnosis of Antibody-mediated Rejection — cfDNA-DSA  

Kidney Transplant Rejection Clinical Trial

Official title:
Donor-derived Cell-free DNA for Early Diagnosis of Antibody-mediated Rejection in Kidney Transplant Recipient With Donor-specific Antibodies

Clinical Trial Summary

Patients after kidney transplantation who develop donor-specific antibodies (DSA) are at high risk for antibody-mediated rejection (ABMR). Donor-derived cell-free DNA (dd-cfDNA) levels have been shown to be increased in patients with active or chronic active ABMR. This study aims to evaluate if repeated analysis of dd-cfDNA in patients with DSA and kidney allograft biopsy which is triggered by increased levels of dd-cfDNA can lead to early diagnosis of active or chronic active ABMR among these patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04897438
Study type Interventional
Source Charite University, Berlin, Germany
Contact
Status Active, not recruiting
Phase N/A
Start date June 1, 2021
Completion date September 1, 2024
View Details
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