Acute Kidney Injury in Poly Trauma Patients

Kidney Injury Clinical Trial

Official title:

Acute Kidney Injury in Poly Trauma Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06108765
• Other study ID #: Acute kidney injury in trauma
• Status: Not yet recruiting
• Start date: November 1, 2023
• Est. completion date: December 1, 2024

Study information

• Verified date: October 2023
• Source: Assiut University
• Contact: Nermeen Gamal
• Phone: 01274524886
• Email: nermeen.14224153[@]med.aun.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to identify the incidence and the factors associated with acute kidney injury in adult poly trauma patients

Description:

Trauma causes significant morbidity and mortality in all age groups but particularly for those below 60 years and is one of the top 5 causes of death (1,2).Most deaths occur in adults who are between 15 and 44 years(3).Polytrauma originates from the Greek words poly which means multiple and trauma which means wounds. The term polytrauma, which was defined using the new Berlin definition, as cases with an Abbreviated Injury Scale (AIS)≥3 for two or more different body regions and one or more additional variables from five physiologic parameters (hypotension[systolic blood pressure≤90 mmHg], unconsciousness[Glasgow Coma Scale score≤8], acidosis [base excess≤ -6.0], coagulopathy [partial thromboplastin time≥40 s or international normalized ratio≥1.4], and age [≥70 years]) [4].There are complex pathophysiological changes that happen in a polyrauma patient which requires effective treatment for improving morbidity and mortality outcomes. Hemorrhage, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are some of the complications of trauma whose effects are not only local but also systemic. There are mechanisms and triggers which result in cardio-vascular shock, hemostasis, apoptosis, organ dysfunctions and immune suppression (CHAOS) [5]. These local and systemic pathophysiological changes that occur in polytrauma (CHAOS) eventually lead to Acute Kidney Injury (AKI) which further worsens their outcomes [6,7].

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: December 1, 2024
• Est. primary completion date: November 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 80 Years

Eligibility

Inclusion Criteria:

• The present study will be conducted on patients with multiple trauma of both genders "without intently selected certain gender" who have no previous history of kidney disease or chronic illness.

Exclusion Criteria:

• • Patients who are less than 16 years old.
• Patients with preexisting kidney disease or localized individual trauma.
• patients with diabetes and hypertension.
• Patients Post cardiac arrest
• patients leaving the hospital on the same day or transferred to a different hospital will be excluded from this study.
• patients refusing study will be excluded.

Related Conditions & MeSH terms

• Acute Kidney Injury
• Kidney Injury
• Multiple Trauma
• Wounds and Injuries

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (1)

Lopes JA, Jorge S. The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin Kidney J. 2013 Feb;6(1):8-14. doi: 10.1093/ckj/sfs160. Epub 2012 Jan 1. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Determine the incidence of acute kidney injury in poly trauma patients	To identify the incidence and factors associated with acute kidney injury in adult polytrauma patients	7 days