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Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients

Kidney Failure, Chronic Clinical Trial

Official title:
Factors Associated With Interdialytic Blood Pressure Variability in Maintenance Hemodialysis Patients

Clinical Trial Summary

The purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability.

Clinical Trial Description

Hemodialysis patients experience higher rates of cardiovascular morbidity and mortality than the general population and many populations with other chronic diseases. This exceptional risk is explained in part by known risk factors such as diabetes, hypertension, and other uremia-related factors, including vascular calcification and stiffness, autonomic dysfunction, and a high burden of circulating inflammatory mediators. However, additional unidentified risk factors also likely contribute to the disproportionately high prevalence of cardiovascular morbidity in hemodialysis patients. Blood pressure variability may represent one plausible cardiovascular risk factor. Data from nonuremic human populations show an association between greater blood pressure variability and cardiovascular events,nonfatal cardiovascular events,stroke,and increased left ventricular mass. There has been comparatively little work examining the causes and effects of blood pressure variability in hemodialysis populations. So the purpose of this study is to explore the factors associated with interdialytic blood pressure variability in maintenance hemodialysis patients, especially the association between volume status and blood pressure variability. ;

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01674660
Study type Observational
Source Beijing Chao Yang Hospital
Contact Cui TG Taigen, Dr.
Phone 010-85231510
Email fujine_521@sina.com
Status Not yet recruiting
Phase N/A
Start date September 2012
Completion date March 2013
View Details
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