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Protein and Exercise Training in Chronic KIDNEY Disease — PET KIDNEY  

Kidney Diseases Clinical Trial

Official title:
Protein Supplementation and Exercise Training to Increase Muscle Protein Synthesis Rates in Patients With Advanced Chronic Kidney Disease

Clinical Trial Summary

When patients progress to the final stage of chronic kidney disease (CKD) and require hemodialysis treatment, they typically have lost so much muscle function that they are no longer physically independent. However, due to disease- and hemodialysis-related muscle catabolism, dietary protein and exercise interventions are only capable to attenuate the decline in physical function of patients on hemodialysis treatment. Therefore, lifestyle interventions to increase muscle function should be implemented before hemodialysis is required. However, it is still a matter of debate whether muscle protein synthesis rates of patients with advanced CKD can be increased with a patient-tailored dietary protein and exercise intervention.Therefore, the current study will assess MPS rates during habitual lifestyle and during an interventional program including dietary protein and exercise in patients with advanced CKD. In addition, we will compare MPS rates during free-living conditions between patients with advanced CKD and healthy controls.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05482243
Study type Interventional
Source Maastricht University Medical Center
Contact Floris K Hendriks, M.D.
Phone +31655522347
Email f.hendriks@maastrichtuniversity.nl
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date May 31, 2024
View Details
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