Other Clinical Trial - Sargramostim for Myeloid Dendritic Cell Deficiency

Status Terminated

Clinical Trial Summary

The study will determine whether administration of sargramostim will improve myeloid dendritic cell deficiency in various study groups, including healthy subjects and patients with chronic kidney disease, including those with kidney transplants.

Clinical Trial Description

The overall objective of this project is to study the ability of sargramostim to enhance mDC level and function, including subsequent stimulation of T cell responses, in various human subjects with demonstrated myeloid dendritic cell (mDC) and T cell deficiency.

Single center nonrandomized trial with an interrupted time series design involving measures on blood samples from three separate populations before and after administration of sargramostim.

The objective is to determine the safety and dose response of sargramostim administration in healthy participants and in patients with chronic kidney disease (CKD) and kidney transplants.

Additionally to determine whether reversal of mDC/T cell deficiency by sargramostim results in augmented T cell responses in these three groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03063242
Study type	Interventional
Source	University of Florida
Contact
Status	Terminated
Phase	Phase 2
Start date	February 23, 2017
Completion date	September 17, 2018

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