Kidney Diseases Clinical Trial
Official title:
The Effects of the CF Carrier State on the Kidneys and Pancreas
The overarching hypothesis is that CF carriers are at increased risk for developing most of the extrapulmonary conditions associated with CF compared to the general population. Specifically, it is hypothesized that this pilot data will detect subclinical evidence of pancreatic and kidney disorders among CF carriers. This will be determined by bringing CF carriers and controls to the CRU for one visit where they will answer survey questions and undergo laboratory testing. Additionally, they will collect urine and stool samples at home that will be sent to outside laboratories for testing.
Status | Recruiting |
Enrollment | 1250 |
Est. completion date | July 2024 |
Est. primary completion date | July 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility | CF Carrier Inclusion Criteria: - A CF Carrier identified via genetic testing Control Inclusion Criteria: - No previous CF carrier test results Exclusion Criteria: - CF patient status - Unable to speak English - Currently pregnant - Unable to provide written informed consent - Prisoner status - Currently taking any medications for the treatment of diabetes |
Country | Name | City | State |
---|---|---|---|
United States | University of Iowa Hospitals and Clinics | Iowa City | Iowa |
Lead Sponsor | Collaborator |
---|---|
Philip Polgreen | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Comparison of Glucose Values | Comparison of glucose values in cystic fibrosis carrier group vs control group via t-tests. | At baseline | |
Primary | Comparison of Insulin Values | Comparison of insulin values in cystic fibrosis carrier group vs control group via t-tests. | At baseline | |
Secondary | Comparison of C-Reactive Protein Values | Comparison of c-reactive protein values in cystic fibrosis carrier group vs control group via t-tests. | At baseline | |
Secondary | Comparison of Lactoferrin Values | Comparison of lactoferrin values in cystic fibrosis carrier group vs control group via t-tests. | At baseline | |
Secondary | Comparison of Calprotectin Values | Comparison of calprotectin values in cystic fibrosis carrier group vs control group via t-tests. | At baseline | |
Secondary | Comparison of Lipid Values | Comparison of lipid values in cystic fibrosis carrier group vs control group via t-tests. | At baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
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