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Ketosis clinical trials

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NCT ID: NCT05665855 Completed - Exercise Clinical Trials

The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Intensity

Start date: December 27, 2022
Phase: N/A
Study type: Interventional

Diet can alter blood ketone levels and this in turn may affect exercise capacity. This study will determine if the acute ingestion of a ketone supplement alters cycling exercise efficiency. Participants will perform three trials in a randomized order. Each trial will involve an incremental exercise protocol on a stationary cycle ergometer to volitional fatigue. Participants will ingest either a high or low dose of a ketone supplement or a taste-matched placebo drink prior to exercise. Blood samples will be obtained to assess selected metabolic responses. This study will provide information regarding the effect of ketone supplementation on exercise efficiency.

NCT ID: NCT05662865 Recruiting - Ketones, Metabolism Clinical Trials

Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers

CASINO
Start date: March 16, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to help us better understand how plasma ketones respond to a low-carb diet when combined with an SGLT2 inhibitor.

NCT ID: NCT05656339 Recruiting - Insulin Resistance Clinical Trials

Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

This study aims to investigate the early metabolic effects and acute phase response of an oral clear supplement containing whey protein plus carbohydrates in young healthy volunteers during fasting-induced organic response

NCT ID: NCT05649891 Not yet recruiting - Pneumonia Clinical Trials

Checklists Resuscitation Emergency Department

Start date: September 2023
Phase: N/A
Study type: Interventional

The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.

NCT ID: NCT05597605 Completed - Clinical trials for Diabetes Mellitus, Type 2

The SHINE Study: Safety of Implant and Preliminary Performance of the SHINE SYSTEM in Diabetic Subjects

Start date: September 21, 2022
Phase: N/A
Study type: Interventional

The objectives of SHINE study are to confirm the safety aspects of the SHINE SYSTEM. Moreover, the goal of this clinical investigation is the initial evaluation of sensor's performance by assessing sensor's ability to qualitatively detect the appropriate analytes in subjects with diabetes of 18 years and older.

NCT ID: NCT05588427 Completed - Hypoxia Clinical Trials

Effect of Ketone Ester Supplementation on Hypoxic Tolerance

Start date: November 15, 2022
Phase: N/A
Study type: Interventional

This WP specifically aims to elucidate the effects of IEK on hypoxic tolerance and the development and severity of AMS symptoms, blood and tissue oxygenation status, as well as sleep quality during an episode of acute exposure to severe hypoxia.

NCT ID: NCT05584371 Recruiting - Exogenous Ketosis Clinical Trials

Evaluation of the Safety and Tolerability of Exogenous Ketosis Induced by Free Beta-hydroxybutyrate.

Start date: October 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the safety and tolerability of free beta-hydroxybutyrate induced ketosis in healthy individuals. The main question it aims to answer is: - Is free beta-hydroxybutyrate safe and well tolerated by adults? Participants will be asked to ingest 10 grams of beta-hydroxybutyrate, diluted in water and sweetened with Stevia, every morning between 9:00 and 11:00 for four weeks.

NCT ID: NCT05581043 Completed - Ketosis Clinical Trials

Pre-meals of 3-hydroxybutyrate in Type 2 Diabetes

PreKetone
Start date: January 12, 2023
Phase: N/A
Study type: Interventional

Hyperglycemia following meals in patients with type 2 diabetes mellitus (T2DM) is a common problem. Recently, our group found that oral consumption of the ketone metabolite, 3-hydroxybutyrate (3-OHB), effectively stimulates insulin secretion and delays gastric emptying.The aim of this study is to investigate the dose/response relationship between 3-OHB servings of 0, 10, 20 and 40 grams 30 minutes before an OGTT and, ii) investigate the role of timing by serving 20 grams of 3-OHB at different timepoints ahead of an OGTT (0, 30 and 60 minutes)

NCT ID: NCT05558488 Completed - Insulin Resistance Clinical Trials

The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response

Start date: October 1, 2019
Phase: N/A
Study type: Interventional

The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the doctoral dissertation, it was considered how to modify a standard ketogenic diet rich in saturated fatty acids so that the use of this model of nutrition has the most anti-inflammatory effect. Therefore, it was decided to conduct a research to check whether a diet rich in omega-3 polyunsaturated fatty acids will show such an effect when following a high-fat diet. Hypotheses: 1. The ketogenic diet reduces systemic inflammation. 2.The ketogenic diet reduces oxidative stress. 3. The ketogenic diet reduces body fat. 4. A ketogenic diet does not worsen strength performance.

NCT ID: NCT05518448 Completed - Diabetes Mellitus Clinical Trials

The Effect of a Ketone Drink on Liver Glucose Production in People With Type 2 Diabetes

KES2
Start date: May 3, 2022
Phase: N/A
Study type: Interventional

What is the effect of a ketone drink on liver glucose production, and postprandial glycemia, in people with type 2 diabetes.