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Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter

Depression Clinical Trial

Official title:
Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter and Its Relevance for Rapid Antidepressant Response

Clinical Trial Summary

The study at hand is the first to investigate ketamine's SERT binding in humans, by utilizing the highly selective SERT radioligand [11C]DASB and positron emission tomography.

Clinical Trial Description

Intravenous application of ketamine is currently dramatically gaining in significance as a rapid and highly effective antidepressant treatment option. Ketamine modulates various neurotransmitter systems, though the mechanisms responsible for its antidepressant effects remain unkownn. However, the serotonin transporter (SERT) presents a target of high interest due to the SERT's fundamental role in depression's pathophysiology as well as in antidepressant response. The study at hand is the first to investigate ketamine's SERT binding in humans, by utilizing the highly selective SERT radioligand [11C]DASB and positron emission tomography. Further, investigation of severely depressed patients provides the unique opportunity to establish the relationship between ketamine's SERT binding and its antidepressant efficacy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02717052
Study type Interventional
Source Medical University of Vienna
Contact Rupert Lanzenberger, Prof.
Phone 014040035760
Email rupert.lanzenberger@meduniwien.ac.at
Status Recruiting
Phase Phase 2
Start date May 2016
Completion date December 31, 2019
View Details
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