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Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice

Jaundice Clinical Trial

Official title:
Effect of Methylene Blue on Perioperative Organ Function in Patients With Obstructive Jaundice

Clinical Trial Summary

Increased production of vasodilating substances such as NO plays an important role in the development of vasoplegic syndrome caused by obstructive jaundice.Methylene blue plays a role in raising blood pressure by inhibiting the vasodilator Nitric Oxide (NO)

Clinical Trial Description

The level of circulating hydrogen sulfide (H2S) in patients with obstructive jaundice is significantly increased. As a direct opener of KATP channels in vivo, H2S also has diastolic peripheral vasculature . H2S participates in the occurrence of vasoplegic syndrome in patients with obstructive jaundice by interacting with NO. However, it is unclear whether methylene blue can relieve vasoplegic syndrome in patients with obstructive jaundice by inhibiting the vasodilating effect of substances such as H2S and NO.

Therefore, this clinical study intends to include patients with obstructive jaundice, using randomized, controlled, prospective study to explore the effect of methylene blue on the occurrence of vasoplegic syndrome, organ function and prognosis in patients with obstructive jaundice. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04109859
Study type Interventional
Source Southwest Hospital, China
Contact
Status Enrolling by invitation
Phase Phase 1
Start date April 1, 2019
Completion date January 21, 2021
View Details
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