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Jaundice clinical trials

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NCT ID: NCT06451900 Completed - Neonatal Jaundice Clinical Trials

Role of Fenofibrate in Neonatal Jaundice

Start date: July 1, 2023
Phase: Phase 4
Study type: Interventional

Fenofibrate appears to be an effective and safe drug for the treatment of neonatal hyperbilirubinemia. It has been proven that it decreases the duration of phototherapy and thus shortens the length of hospital stay. This study was performed to study the prophylactic role of fenofibrate in prevention of neonatal jaundice.

NCT ID: NCT06386731 Completed - Neonatal Jaundice Clinical Trials

Continuous Versus Intermittent Phototherapy in Treatment of Neonatal Jaundice

Start date: July 5, 2022
Phase: N/A
Study type: Interventional

One of the most common diseases in the neonatal period is indirect hyperbilirubinemia (IHB). After phototherapy was discovered accidentally in 1958, it has been used as the most effective treatment method for IHD for more than 60 years. Sources that provide phototherapy are developing rapidly technologically. However, there is no clearly defined usage table in the literature for applying phototherapy with faster effects and fewer side effects. In recent years, the use of intermittent phototherapy has been recommended with similar effectiveness. Phototherapy has significant side effects such as dehydration, diarrhea, chromosome breaks, retinal damage, skin rashes, hypocalcemia, thrombocytopenia. As phototherapy exposure decreases, its side effects decrease.In our study; We plan to find the most ideal method in the treatment of IHB by comparing intermittent PT with continuous phototherapy in terms of effectiveness. We aim to achieve the best bilirubin reduction and minimal side effects with less exposure to phototherapy.

NCT ID: NCT06372093 Completed - Jaundice, Neonatal Clinical Trials

Evaluation of Bilirubin Measurements in Newborns From Smartphone Digital Images in a Population in Botswana

Start date: March 16, 2023
Phase: N/A
Study type: Interventional

The general objective of this study is to evaluate the accuracy of a novel smartphone application for jaundice screening (Picterus Jaundice Pro) in a population with high melanin content in the skin. The specific objectives for this study are: i. To assess the correlation between bilirubin level measurements obtained by Picterus Jaundice Pro with Total Serum Bilirubin (TSB), and TcB, in newborns with high melanin content in the skin. ii. To determine the accuracy of Picterus Jaundice Pro in newborns with high melanin content in the skin.

NCT ID: NCT06227624 Completed - Neonatal Jaundice Clinical Trials

Role of Oral Zinc in Reducing Neonatal Indirect Hyperbilirubinemia

Start date: June 1, 2018
Phase: Phase 3
Study type: Interventional

This study aimed to determine the role of oral zinc in reducing the neonatal indirect hyperbilirubinemia if used concomitant with the standard phototherapy

NCT ID: NCT05919303 Completed - Clinical trials for Radiological Correlation of Obstructive Jaundice

Multidetector Computed Tomography (MDCT) Evaluation of Obstructive Jaundice: A Cross-sectional Study From a Tertiary Hospital of Nepal

Start date: October 8, 2019
Phase:
Study type: Observational

This study was done to evaluate the diagnostic statistics of MDCT and its features in the assessment of obstructive jaundice in reference to surgical or histopathological diagnosis.

NCT ID: NCT05692648 Completed - Newborn Jaundice Clinical Trials

Effect of Repositioning Frequency Neonates Receiving Phototherapy

Start date: February 1, 2020
Phase: N/A
Study type: Interventional

Purpose: The present study was conducted to determine the effect of repositioning frequency during phototherapy on bilirubin level and neonates comfort. Design and methods: This was a single-centered, single-blind, 3-arm, pretest-posttest parallel-group randomized controlled trial conducted in a neonatal intensive care unit. Participants were randomly assigned to one of three groups: Supine position group (n = 20), hourly position change group (n = 20), and control group (n = 20). The bilirubin level and comfort levels of the neonates were evaluated.

NCT ID: NCT05650463 Completed - Jaundice, Neonatal Clinical Trials

Evaluation of a Smartphone-based Screening Tool (Picterus Jaundice Pro) for Neonatal Jaundice in Dark Skin Newborns

Start date: November 29, 2021
Phase: N/A
Study type: Interventional

A cross-sectional study at the Södersjukehuset facility (Stockholm, Sweden) collect data of newborns from a population with Neomar scale type 4 to adjust the algorithm of Picterus JP

NCT ID: NCT05625880 Completed - Jaundice, Neonatal Clinical Trials

Evaluation of Bilirubin Estimates in Newborns From Smartphone Digital Images in a Nepali Population

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

This cross-sectional study evaluates the accuracy of a novel smartphone application that estimates bilirubin levels in newborns at Dhulikhel Hospital, Kathmandu Nepal.

NCT ID: NCT05623553 Completed - Jaundice, Neonatal Clinical Trials

Evaluation of a Smartphone Based Diagnostic Tool to Assess Neonatal Jaundice in a Mexican Population

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

This corss-sectional study aims to test the performance and accuracy of the Picterus JP screening device in newborns with different skin types.

NCT ID: NCT05616845 Completed - Jaundice, Neonatal Clinical Trials

A mHealth Application as a Screening Tool for Neonatal Jaundice in Filipino Neonates

Start date: February 2, 2022
Phase: N/A
Study type: Interventional

The purpose of the study is to test the reliability of the Picterus smartphone application in Filipino neonates. A descriptive cross-sectional study will be the method to understand the correlation of the modalities and to determine the reliability of the application