Infertility Clinical Trial
Official title:
Early Follicular GnRH Antagonist Supplementation Improves Fertilization and Embryo Cleavage Rates in IVF-ET GnRH Antagonist Cycles
Our goal was to investigate whether early follicular supplementation of the GnRH antagonist to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical results
GnRH antagonist offers many advantages when used in IVF-ET treatment, however, it is
suspected to yield lower pregnancy rate when compared with the long GnRH agonist protocol.
Our goal was to investigate whether early follicular supplementation of the GnRH antagonist
to the flexible GnRH antagonist protocol, has a potential to improve IVF-ET clinical
results.
Consecutive patients are prospectively enrolled and randomly assigned to the study and
control groups. Patients with low ovarian reserve or with uterine distortion are excluded
from the study. Both groups are treated with recombinant FSH and the flexible GnRH
antagonist protocol. Women in the study group are also treated with additional GnRH
antagonist 0.25 mg/day on day 1, 2 and 3 of the menstrual cycle.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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