ITP Clinical Trial - Anti-BCMA CAR T-Cell Therapy for R/R ITP

Status Recruiting

Clinical Trial Summary

This is a prospective, single-center, open-label, single-arm study, to evaluate the efficacy and safety of Anti-BCMA chimeric antigen receptor T cell therapy（BCMA CAR-T）for patients with relapse/refractory Immune thrombocytopenia(R/R ITP).

Clinical Trial Description

Immune thrombocytopenia (ITP) is a disorder that can lead to easy or excessive bruising and bleeding. Approximately two-thirds of patients achieve remission after/during first-line therapies. However, the other part of patients could not achieve durable remission or even refractory to initial treatments. Those cases, known as relapse/refractory Immune thrombocytopenia (R/R ITP), undergo the heavy burden of disease which decreases the quality of life. Lots of pathogeneses take part in the occurrence of R/R ITP, and the most important one of them is antibody-mediated immune platelet destruction. As far as it is known，human platelet autoantibodies are mainly secreted by plasma cells, especially long-lived plasma cells. Researchers want to explore that can BCMA CAR-T help R/R ITP patients increase platelet count, reduce bleeding episodes and the dose of concomitant medications. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05315778
Study type	Interventional
Source	The First Affiliated Hospital of Soochow University
Contact
Status	Recruiting
Phase	Phase 2
Start date	January 1, 2022
Completion date	June 30, 2023

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See also
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