Clinical Trials Logo

Clinical Trial Summary

This is a prospective, single-center, open-label, single-arm study, to evaluate the efficacy and safety of Anti-BCMA chimeric antigen receptor T cell therapy(BCMA CAR-T)for patients with relapse/refractory Immune thrombocytopenia(R/R ITP).


Clinical Trial Description

Immune thrombocytopenia (ITP) is a disorder that can lead to easy or excessive bruising and bleeding. Approximately two-thirds of patients achieve remission after/during first-line therapies. However, the other part of patients could not achieve durable remission or even refractory to initial treatments. Those cases, known as relapse/refractory Immune thrombocytopenia (R/R ITP), undergo the heavy burden of disease which decreases the quality of life. Lots of pathogeneses take part in the occurrence of R/R ITP, and the most important one of them is antibody-mediated immune platelet destruction. As far as it is known,human platelet autoantibodies are mainly secreted by plasma cells, especially long-lived plasma cells. Researchers want to explore that can BCMA CAR-T help R/R ITP patients increase platelet count, reduce bleeding episodes and the dose of concomitant medications. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05315778
Study type Interventional
Source The First Affiliated Hospital of Soochow University
Contact
Status Recruiting
Phase Phase 2
Start date January 1, 2022
Completion date June 30, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT05281068 - The Combination of Iguratimod and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia Phase 2
Recruiting NCT05635266 - Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
Completed NCT02914054 - Therapy of Adults Affected by Idiopathic Thrombocytopenic Purpura With Dexamethasone Phase 2/Phase 3
Recruiting NCT05116423 - Machine-learning Based Prediction Model in Primary Immune Thrombocytopenia
Terminated NCT04904276 - Observational Study of Fostamatinib as Second Line Therapy in Adult Patients With Immune Thrombocytopenia (ITP) and Insufficient Response to a Prior Therapy
Recruiting NCT04747080 - The Combination of Tacrolimus and High-dose Dexamethasone as First-line Treatment in Adult Immune Thrombocytopenia Phase 2
Not yet recruiting NCT04482777 - IL37,Tlymphocytes,NK Cells in Pathogenesis of ITP
Recruiting NCT05446831 - Baricitinib for Steroid-resistant/Relapse Immune Thrombocytopenia Phase 2
Active, not recruiting NCT04703621 - The DART Study- Daratumumab Treatment in ITP Phase 2
Recruiting NCT05118126 - Gut Microbiota in ITP
Active, not recruiting NCT04943042 - An Observational, Multicenter Study to Evaluate the Use and Effectiveness of Doptelet® in Patients With ITP
Completed NCT04089267 - Evaluating the Efficacy and Safety of Different Human Thrombopoietin (rhTPO) Regimens in the Treatment of Patients With Primary Immune Thrombocytopenia (ITP) Phase 4
Recruiting NCT04735588 - Investigation on the Incidence and Course of COVID-19 in Patients With Prior, Ongoing or de Novo ITP. Evaluation of the Impact of COVID-19 Pandemic on the Management of ITP