Ischemic Reperfusion Injury Clinical Trial
Official title:
Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace
The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
Methods: Patients meeting the requirement will be randomized into 2 groups: the treatment group consisted of three 5-minute cycles left lower limb ischemia, induced by inflating a blood pressure cuff on the lower limb to 600 mmHg with an intervening 5 minutes of reperfusion, during which time the cuff was deflate; the control group consisted of placing an uninflated cuff on the left lower limb for 30 minutes. The postconditioning protocol was applied after the aortic cross-clamping. The clinical data of inotropes requirement, drainage, ventilation and intensive care time will be recorded. Venous blood samples will be taken perioperatively for detecting concentration of troponin I (cTnI), Myocardial enzyme, Renal function, Cystatin c, and High-sensitivity c-reactive protein(HS-CRP). ;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02134314 -
C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI
|
Phase 1/Phase 2 | |
| Completed |
NCT03050489 -
Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG
|
||
| Recruiting |
NCT02940600 -
Efficacy Evaluation of Normothermic Perfusion Machine Preservation in Liver Transplant Using Very Old Donors
|
N/A | |
| Recruiting |
NCT02729155 -
Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
|
N/A | |
| Recruiting |
NCT02649309 -
Single-cycle Remote Ischemic Preconditioning and Postconditioning (SCRIP) Trial
|
N/A | |
| Completed |
NCT02290080 -
Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction by Biomarkers
|
Phase 3 | |
| Not yet recruiting |
NCT04068116 -
Impact of Ischemic Post-conditioning
|
N/A | |
| Terminated |
NCT01726465 -
Methylprednisolone N Acetylcysteine in Hepatic Resections
|
Phase 2 | |
| Completed |
NCT03535623 -
RIPC During Free Flap With Preoperative Radiotherapy
|
N/A | |
| Completed |
NCT02581618 -
Remote Ischemic Preconditioning in Elective Percutaneous Interventions
|
N/A | |
| Recruiting |
NCT04000334 -
Early Transcranial Doppler Goal Directed Therapy After Cardiac Arrest: a Pilot Study
|
N/A | |
| Completed |
NCT01887171 -
Evaluation of Preimplantation Portal Vein and Hepatic Artery Flushing With Tacrolimus
|
N/A | |
| Recruiting |
NCT05148715 -
Calcineurin Inhibitor in NEuRoloGically Deceased Donors to Decrease Kidney delaYed Graft Function (CINERGY)
|
Phase 2 | |
| Recruiting |
NCT05661227 -
Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion
|
N/A | |
| Completed |
NCT04257240 -
Recurrence of Liver Malignancy After Ischemia/Reperfusion Injury
|
||
| Active, not recruiting |
NCT05708053 -
Cardio-protective Effect of Metformin in Patients Undergoing PCI
|
Phase 3 | |
| Completed |
NCT05194306 -
PERTRIAL - Perla® Preservation Solution
|
N/A | |
| Recruiting |
NCT05179434 -
A Study of Retrograde Reperfusion of Renal Graft to Reduce Ischemic-reperfusion Injury
|
N/A | |
| Not yet recruiting |
NCT04951791 -
Lipid Emulsion in Cardiac Valve Replacement Surgery
|
N/A | |
| Completed |
NCT01666587 -
Ischemia Reperfusion: Prostaglandins and Antioxidants
|
N/A |