Ischemia Clinical Trial
Official title:
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx
of blood flow. syndecan-1 was a marker of glycocalyx.
The purpose of this study is to prove the variation of level of serum syndecan-1 between
preoperative and postoperative period.
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml
of blood sample was obtained for total 6 times in consecutive order.
1. Preoperation (immediate before anesthesia induction)
2. Immediate before tourniquet off
3. 5 min after tourniquet off
4. PACU
5. postoperative 6 hours
6. postoperative 24 hours
Serum in blood will be obtained and level of serum cytokine will be evaluated by
enzyme-linked immunosorbent assay
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