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Irritation/Irritant clinical trials

View clinical trials related to Irritation/Irritant.

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NCT ID: NCT06119750 Completed - Healthy Clinical Trials

4-Day Primary Irritation Patch Test of MIS Solution

Start date: July 6, 2020
Phase: N/A
Study type: Interventional

This is a 7 day primary irritation patch test. This study investigates the irritation potential of Next Science MIS Wound Irrigation Solution under standardized conditions compared with an inert control (normal saline) and a known irritant, 20% sodium dodecyl sulfate (also known as sodium lauryl sulfate [SLS]) solution in deionized water [DI] water) on intact skin of healthy human subjects.

NCT ID: NCT05276102 Recruiting - Irritation/Irritant Clinical Trials

The Effects of Repeated Exposure to Antiseptics During COVID-19 Pandemic on Skin Parameters

Start date: March 7, 2022
Phase: N/A
Study type: Interventional

The global coronavirus disease pandemic (COVID-19) has led to an increased need to wear protective equipment such as wearing face masks and practicing hygiene measures such as more frequent use of antiseptics. These measures can lead to changes in the skin, the development of new inflammatory skin diseases or exacerbation of existing ones, with health professionals especially under the risk of developing these changes. Changes in the skin of the hands due to the use of antiseptics have been observed in a number of studies, however, part of the study was based solely on subjects' self-assessment or clinical assessment of researchers, and only a small part on objective measurements of skin parameters. Also, the impact of prolonged use of antiseptics and the impact of measures to prevent and protect against irritation such as topical application of emollient preparations have not been investigated. The impact of repeated use of antiseptics in the repeated exposure model on the forearms will be investigated. This model is a modification of the existing model of irritative dermatitis induced by sodium lauryl sulfate where the original irritant was replaced by an antiseptic solution.

NCT ID: NCT05079607 Completed - Sensitisation Clinical Trials

Human Skin Safety Testing of a Mitopure Topical Product Using a Human Repeat Insult Patch Test (HRIPT) in Healthy Volunteers

GLOW-Safety
Start date: October 4, 2021
Phase: N/A
Study type: Interventional

The objective of this study is to investigate the irritation and sensitization potential of multiple topically applied test articles (containing different concentrations of Mitopure), in a shared panel of healthy volunteers by means of repeated cutaneous patch applications under occlusion based on the modified Draize method

NCT ID: NCT02198963 Completed - Irritation/Irritant Clinical Trials

21 Day Cumulative Skin Irritation of RUT058-60

Start date: July 2014
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the skin irritation potential of RUT058-60 after repetitive patch application to abraded and non-abraded skin of human subjects.

NCT ID: NCT00916383 Completed - Irritation/Irritant Clinical Trials

Study in Elderly Alzheimer's Patients to Assess Skin Tolerability, Irritation With 3, 7-Day Applications of DTP-System

DTP-System
Start date: May 2009
Phase: Phase 2
Study type: Interventional

This study is designed to assess skin tolerability, skin irritation, and adhesion of the 350 mg Donepezil Transdermal Patch (DTP-system), following 3, 7-day applications to 3 specific areas of the body (upper back, upper middle arm, side of torso) of elderly Alzheimer's patients. The total application time for the DTP-system is 21 days.