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Pilot Study of the Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome — IBS  

Irritable Bowel Syndrome Clinical Trial

Official title:
Pilot Study of the Physiological Effects of an Integrative Medicine Approach in Irritable Bowel Syndrome

Clinical Trial Summary

Although underutilized, what is emerging as one of the best ways of evaluating inflammation in the body, particularly in difficult to observe regions, is through the use of Fluorodeoxyglucose (FDG) positron emission tomography (PET). FDG is taken up in the body much like glucose and is particularly taken up in areas of inflammation where there is increased metabolism. Therefore, this technology can be used to assess inflammation, and measure the reduction in inflammation as the result of integrative interventions that target dietary modifications designed to reduce inflammation. With this proposed study, we plan to use FDG PET-MRI technology to develop a more specific and sensitive approach for evaluating areas of inflammation associated with IBS and measuring improvements in that inflammation in response to effective integrative interventions.

Clinical Trial Description

The typical goal of the integrative medicine approach is to develop an individualized plan to help restore homeostasis to the gastrointestinal system targeting a reduction in inflammation as an important element in helping to relieve symptoms. One of the most problematic issues though is to determine where in the GI tract the inflammation is occurring and then evaluating improvements in inflammation as any intervention proceeds. Participants will undergo a small battery of diagnostic tests that include magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (FDG-PET). A secondary goal of this study is to evaluate the utility of FDG PET-MRI for assessing reductions in inflammation in patients managed with an integrative medicine approach based upon diet and nutritional counselling. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03370614
Study type Observational
Source Thomas Jefferson University
Contact
Status Active, not recruiting
Phase
Start date May 4, 2017
Completion date June 30, 2025
View Details
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