Multi-strain Probiotic in the Management of IBS-D

Status Completed

Clinical Trial Summary

1. To assess the effect of multistrain probiotics on abdominal pain using a validated symptom severity score in IBS patients.

2. To assess the efficacy of a multi-strain probiotic supplement as a treatment option for IBS in a tertiary referral centre

Clinical Trial Description

Background: Accumulating evidence supports the view that an imbalance of gut bacteria contributes to IBS, and that increasing the mass of beneficial species may reduce the numbers of pathogenic bacteria and help alleviate symptoms.

Methods: In this double-blind trial 360 adult patients with moderate-to-severe symptomatic diarrhea-predominant IBS (IBS-D) were randomized to treatment with the multi-strain probiotic (Bio-Kult®; 14 different bacterial strains; 8 billion colony-forming units per day) or placebo for 16 weeks. The change in severity and frequency of abdominal pain was the primary outcome measure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03251625
Study type	Interventional
Source	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Contact
Status	Completed
Phase	Phase 4
Start date	April 2015
Completion date	April 2016

View Details

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