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Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

Irritable Bowel Syndrome Clinical Trial

Official title:
Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the entérique Nervous System During the Syndrome of the Irritable Bowel

Clinical Trial Summary

Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:

1. paracellular permeability in colonic biopsies of IBS patient

2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00742118
Study type Interventional
Source Centre Hospitalier Universitaire de Nice
Contact Thierry PICHE, PhD
Email piche.t@chu-nice.fr
Status Recruiting
Phase N/A
Start date February 2008
Completion date July 2016
View Details
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