Clinical Trials Logo
  1. Home
  2. Iron Absorption
  3. NCT02197624

Genetic Variants and Iron Absorption

Iron Absorption Clinical Trial

Official title:
Metabolic Adaptation to Plant-based Diets in Asian Populations

Clinical Trial Summary

The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women. The investigators hypothesize that the genetic variant could enhance iron status and iron absorption in Asian women.

Clinical Trial Description

To determine the HFE genotype of female Asian study volunteers, we collected venous blood samples and extracted DNA from these blood samples. HFE genotype was determined as CC, CT, and TT and used to assess possible differences in iron status as a function of genotype. To measure the impact of genotype on non-heme Fe absorption, a sub-group of women with the CC (n=10) or TT (n=11) genotype were invited to return for an Fe absorption study. Each volunteer consumed stable 57Fe (as ferrous sulfate). Two weeks after ingesting this tracer, a blood sample was collected from each woman and the amount of non-heme (57Fe) iron incorporated into red blood cells was measured with magnetic sector thermal ionization mass spectrometry. Possible associations between iron status and iron absorption as a function of genotypes were explored. Data from this study will provide information that aims to improve human health by better understanding the iron requirements of individuals with different genetic background. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02197624
Study type Observational
Source Cornell University
Contact
Status Completed
Phase N/A
Start date June 2012
Completion date May 2014
View Details
See also
  Status Clinical Trial Phase
Completed NCT03310203 - The Relation Between Adiposity, Inflammation, Glycaemia and Iron Absorption N/A
Completed NCT01493297 - Effects of Vitamin A and Carotenoids on Iron Absorption N/A
Active, not recruiting NCT02979132 - Iron Long-Term Labelling Study Switzerland N/A
Completed NCT03586245 - Iron Absorption From Iron Enriched Aspergillus Oryzae in Females Using Stable Isotope Methodology N/A
Completed NCT04774016 - Iron Absorption From an Iron-fortified Follow-up Formula With Added Synbiotic or Human Milk Oligosaccharides N/A
Recruiting NCT06327529 - Zinc and Iron Absorption From Common Beans in Young Adult Women N/A
Active, not recruiting NCT02977806 - Iron Long-Term Labelling Study Malawi
Active, not recruiting NCT02979080 - Iron Long-Term Labelling Study Benin N/A
Recruiting NCT05973552 - Iron Absorption and Requirements in Pregnancy and Lactation
Completed NCT03894358 - Iron Absorption From a Wheat-based Instant Cereal:Gut and Stable Isotope Studies in Kenyan Infants N/A
Completed NCT01489007 - Iron Absorption in Vegetarian Children
Not yet recruiting NCT06236620 - Iron and Zinc Absorption in Flakes Derived From Sprouted or Hydrothermally Processed Wheat N/A
Completed NCT05266703 - Defining the Serum Ferritin Concentration in Kenyan Women at Which the Body Senses Iron Depletion and Begins to Upregulate Iron Absorption N/A
Completed NCT02228902 - Iron Absorption Trial Phase 4
Completed NCT01423162 - Iron Bioavailability of Fortified Oat Drink Phase 4
Completed NCT01483092 - Effect of Inulin on Iron Absorption in Humans N/A
Completed NCT03453918 - Effects of Polyphenols on Iron Absorption in Iron Overload Disorders. N/A