Clinical Trials Logo
  1. Home
  2. Iron Absorption
  3. NCT04774016

Iron Absorption From an Iron-fortified Follow-up Formula With Added Synbiotic or Human Milk Oligosaccharides

Iron Absorption Clinical Trial

Official title:
Iron Absorption From an Iron-fortified Follow-up Formula With and Without the Addition of a Synbiotic or Human Milk Oligosaccharides: a Stable Isotope Study in 10-14 Month-old Thai Children

Clinical Trial Summary

The co-primary objectives of this study are: 1) to investigate the effect adding a synbiotic (combination of a pre-and probiotic) to iron-fortified follow-up formula (FUF) on iron bioavailability, and 2) to investigate the effect adding Human Milk Oligosaccharides (HMOs) to iron-fortified FUF on iron bioavailability in 10-14 month-old Thai children.

Clinical Trial Description

Iron stores of healthy, full-term neonates are supposed to cover iron needs for the first 4-6 months of life. After 6 months of age, requirements for absorbed iron are high, as infants need to build body iron stores and triple their body weight before the first year of life. Iron concentrations in mature breastmilk are low (~0.3 mg/L) and cannot adequately cover the high iron requirements of children between 6 and 24 months of age. Follow-up formulas (FUF) are fortified milk-based products intended for infants above 6 months of age and young children aged 1-3 years, and are widely used as a liquid part of the weaning diet to supplement the diet of young children with macro- and micronutrients. Prebiotics and probiotics are increasingly added to foods for infants and young children due to emerging evidence on possible health benefits. We recently showed that the addition of prebiotic galacto-oligosaccharides (GOS) to an iron-containing micronutrient powder increased iron absorption in Kenyan infants. To our knowledge, the effect of the combination of pre- and probiotics (synbiotic) or human milk oligosaccharides (HMOs) on iron absorption from an iron-fortified FUF has not been investigated. Thai children (10-14 months old) will be assigned to receive FUF fortified with isotopically labelled iron as FeSO4 1) with synbiotic, 2) HMO, and 3) without added prebiotics as a reference, in random order. Besides the iron source and synbiotic or HMO, the test FUF will be identical in terms of macro- and micronutrient composition. For the secondary objectives of this study, which will have a single-group, before-after design, each infant will receive the test FUF with added synbiotic for 25 days on gut comfort and quality of life outcomes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04774016
Study type Interventional
Source Société des Produits Nestlé (SPN)
Contact
Status Completed
Phase N/A
Start date November 18, 2020
Completion date June 7, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT03310203 - The Relation Between Adiposity, Inflammation, Glycaemia and Iron Absorption N/A
Completed NCT01493297 - Effects of Vitamin A and Carotenoids on Iron Absorption N/A
Active, not recruiting NCT02979132 - Iron Long-Term Labelling Study Switzerland N/A
Completed NCT03586245 - Iron Absorption From Iron Enriched Aspergillus Oryzae in Females Using Stable Isotope Methodology N/A
Active, not recruiting NCT02977806 - Iron Long-Term Labelling Study Malawi
Completed NCT02197624 - Genetic Variants and Iron Absorption N/A
Active, not recruiting NCT02979080 - Iron Long-Term Labelling Study Benin N/A
Recruiting NCT05973552 - Iron Absorption and Requirements in Pregnancy and Lactation
Completed NCT03894358 - Iron Absorption From a Wheat-based Instant Cereal:Gut and Stable Isotope Studies in Kenyan Infants N/A
Completed NCT01489007 - Iron Absorption in Vegetarian Children
Not yet recruiting NCT06236620 - Iron and Zinc Absorption in Flakes Derived From Sprouted or Hydrothermally Processed Wheat N/A
Completed NCT05266703 - Defining the Serum Ferritin Concentration in Kenyan Women at Which the Body Senses Iron Depletion and Begins to Upregulate Iron Absorption N/A
Completed NCT02228902 - Iron Absorption Trial Phase 4
Completed NCT01423162 - Iron Bioavailability of Fortified Oat Drink Phase 4
Completed NCT01483092 - Effect of Inulin on Iron Absorption in Humans N/A
Completed NCT03453918 - Effects of Polyphenols on Iron Absorption in Iron Overload Disorders. N/A
Not yet recruiting NCT06327529 - Zinc and Iron Absorption From Common Beans in Young Adult Women N/A