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Iritis clinical trials

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NCT ID: NCT02416128 Withdrawn - Iritis Clinical Trials

Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology

Start date: April 30, 2015
Phase: N/A
Study type: Interventional

The investigators plan to use an herbal eye drop, Euphrasia, aka Eyebright, for post-operative inflammation for Peripheral Laser Iridotomy for the treatment of narrow angle glaucoma. A peripheral Laser Iridotomy is a simple laser procedure with few complications if the patient follows the post-operative instructions. In this procedure, a blue-green Argon laser is used to create an orifice in the iris to open the angle by allowing the aqueous from behind the iris to enter the anterior chamber. Rarely the procedure needs to be repeated. The main complications from this surgery are postoperative inflammation, bleeding, and postoperative pressure spikes. The investigators will be using Weleda's Euphrasia D3 eye drops. The investigators plan to do a double blinded randomized control trial to objectively measure ocular inflammation in the same process that was used for the steroid eye drops that are currently out on the market. Some patients will be receiving steroids, prednisolone acetate, others, the herbal eye drop.

NCT ID: NCT01978015 Completed - Clinical trials for Cystoid Macular Edema

Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG

Start date: October 2011
Phase: Phase 4
Study type: Interventional

Glaucoma, a progressive optic disc neuropathy causing visual field reduction, is the second leading cause of world blindness. The treatment of glaucoma is mainly based in reducing intraocular pressure (IOP) with topical medications. Many patients required two or more medications to achieve a target IOP. Combinations of B-blockers and prostaglandin analogs (PGA) are frequently used in clinical practice because their additive effect in lowering IOP levels. The aim of this study was to investigate the effects of fixed combinations of timolol maleate and PGA on the blood-aqueous barrier and evaluate the measurement of foveal thickness in pseudophakic patients with primary open-angle glaucoma (POAG).

NCT ID: NCT01647529 Completed - Anterior Uveitis Clinical Trials

Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis

Virgan
Start date: July 2012
Phase: N/A
Study type: Interventional

Objective of this study is to investigate the intracameral level of ganciclovir following topical application of 0.15% ganciclovir gel (VIRGAN©) for Cytomegalovirus (CMV) anterior uveitis and endothelitis. Thirty patients who are diagnosed with CMV anterior segment infection, either uveitis or endothelitis, who have a positive aqueous real time PCR (RT-PCR) and/or positive tetraplex PCR for CMV and have not had any form of ganciclovir treatment in the past 1 month, will be recruited in the study after taking an informed consent. with active CMV anterior segment infection confirmed by a positive aqueous real time PCR (RT-PCR) and have not had any form of ganciclovir treatment in the past 1 month were recruited in the study. Patients were given 0.15% ganciclovir gel 1cc 5 times a day for 6 weeks. Following 6 weeks of treatment, tears and aqueous samples will be collected. Aqueous will be sent for RT-PCR for CMV status. Ganciclovir drug level in both tears and aqueous will be measured by HPLC method. Clinically, degree of the intraocular inflammation, Intraocular pressure (IOP) and central corneal thickness (CCT) will be recorded at baseline and post-treatment.

NCT ID: NCT01505088 Completed - Anterior Uveitis Clinical Trials

Safety and Efficacy Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution to Treat Non-Infectious Anterior Segment Uveitis

Start date: December 2011
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution EGP-437 using the EyeGate® II Drug Delivery System (EGDS) compared to prednisolone acetate ophthalmic suspension (1%) in patients with non-infectious anterior segment uveitis.

NCT ID: NCT01486693 Recruiting - Anterior Uveitis Clinical Trials

Clinical Outcomes of Topical Ganciclovir Treatment in Cytomegalovirus Anterior Uveitis

Start date: October 2011
Phase: N/A
Study type: Observational

The purpose of this study was to evaluate long term efficacy and safety of topical ganciclovir treatment in Cytomegalovirus (CMV) anterior uveitis.

NCT ID: NCT01376362 Completed - Uveitis Clinical Trials

Topical Interferon Gamma for Macular Edema Secondary to Uveitis

JakStat2
Start date: June 2011
Phase: Phase 1/Phase 2
Study type: Interventional

The objective of this study is to investigate the safety and efficacy of ocular instillations of interferon gamma-1b as a potential treatment for cystoid macular edema (CME) secondary to uveitis.

NCT ID: NCT01201798 Completed - Clinical trials for Endogenous Anterior Uveitis

Safety and Efficacy of Difluprednate 0.05% for the Treatment of Anterior Uveitis

Start date: October 2010
Phase: Phase 3
Study type: Interventional

The purpose of this study was to demonstrate that difluprednate 0.05% (Durezol) dosed 4 times daily is noninferior to prednisolone 1% (Pred Forte) dosed 8 times daily for the treatment of endogenous anterior uveitis.

NCT ID: NCT01156285 Recruiting - Anterior Uveitis Clinical Trials

Acute Anterior Uveitis: Psychic Burden and Pain

Start date: May 2010
Phase: N/A
Study type: Observational

Acute anterior uveitis (AU) is a common reason for attendance at ophthalmic outpatient clinics. The painfulness and the fear of a transient or even persistent loss of vision may markedly reduce the individual's subjective well-being and pose a psychological burden. This study will test the hypothesis that during an attack of AU the patient experiences a marked reduction in psychological and physical well-being. Prospective, hospital-based epidemiologic study using a patient questionnaire with standardized psychological tests and a pain scale.

NCT ID: NCT01154010 Completed - Anterior Uveitis Clinical Trials

PEMF: an Adjunct Therapy for Anterior Uveitis

PEMF
Start date: August 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if a medical device (ActiPatch) that emits a low frequency pulsed electromagnetic field (PEMF) will benefit patients with anterior uveitis. Anterior uveitis (aka iritis) is an inflammatory disease involving the front segment of the eye. This is a common cause of a painful red eye, and ActiPatch has been shown to be effective in treating tissue inflammation. The conventional treatment of iritis typically involves frequent administration of topical steroids which have their own inherent risks (development of cataracts and/or glaucoma). The purpose of this study is to determine if ActiPatch therapy can be used to shorten the length of time and/or quantity of steroids administered.

NCT ID: NCT00823173 Completed - Anterior Uveitis Clinical Trials

Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis

Start date: January 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether ESBA105, a topically applied TNF-alpha inhibitor, is safe and clinically active when applied to the eye of patients suffering from acute anterior uveitis