Estimating Usual Iodine Intake From Spot Urinary Iodine Concentrations

Iodine Deficiency Clinical Trial

— ITURN  

Official title:

Estimating the Usual Iodine Intake From Spot Urinary Iodine Concentrations to Obtain the Prevalence of Inadequate or Excess Iodine Intake in School-aged Children and Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03602404
• Other study ID #: ITURN
• Status: Completed
• Start date: June 1, 2018
• Est. completion date: February 21, 2020

Study information

• Verified date: May 2022
• Source: Swiss Federal Institute of Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The overall objective of this study is to develop a reliable method to obtain habitual iodine intakes from spot urinary iodine concentration (UIC) and to assess the prevalence of inadequate iodine intake in school-age children and women of reproductive age. We will evaluate different methods to estimate iodine intake from UIC and estimate the prevalence of inadequate and excess iodine intake in UIC studies conducted in populations with low, adequate and high iodine intakes using the the established estimated average requirement (EAR)/Tolerable Upper Intake Level (UL) cut-point method.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1592
• Est. completion date: February 21, 2020
• Est. primary completion date: February 21, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 9 Years to 13 Years

Eligibility

Inclusion Criteria:

• lived in study area >= 12 months
• no reported intake of Amiodarone
• no history of thyroid dysfunction / goiter (past & present)
• no exposure to iodine containing contrast agents within the last 12 months Second arm: Women aged 18 - 49, exclusion / inclusion criteria apply, plus non-pregnant, non-lactating.

Related Conditions & MeSH terms

• Iodine Deficiency

Locations

Country	Name	City	State
Papua New Guinea	University of Papua New Guinea	Sia	Morobe
Russian Federation	Almazov Medical Research Center	Saint Petersburg

Sponsors (3)

Lead Sponsor	Collaborator
Swiss Federal Institute of Technology	Almazov National Medical Research Centre, University of Papua New Guinea

Countries where clinical trial is conducted

Papua New Guinea,  Russian Federation, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Estimated iodine intake	Estimated daily iodine intake of the study population derived from urinary iodine and creatinine concentrations measured in spot urine samples	17 months
Secondary	Urinary iodine concentration	Measured in spot urine samples and 24 h urine collections	17 months
Secondary	Urinary creatinine concentration	Measured in spot urine samples and 24 h urine collections	17 months