Climat Impact on Urinary Iodine Concentration

Iodine Deficiency Clinical Trial

— LION  

Official title:

Assessment of Impact of High Temperature Climate on Urinary Iodine Concentration in Women of Reproductive Age

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03215680
• Other study ID #: LION
• Status: Completed
• Start date: July 10, 2017
• Est. completion date: December 31, 2018

Study information

• Verified date: March 2021
• Source: Swiss Federal Institute of Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Urinary iodine concentration (UIC) is the recommended biomarker of iodine status in populations. Yet, the influence of climate on UIC remains unclear. Hot climate may reduce urine volume and consequently increase UIC independent of iodine status. This could lead to an overestimation of population iodine intake, thus masking iodine deficiency in vulnerable groups.

In this longitudinal observational cohort study in women of reproductive age we will collect 24h and spot urine samples in the summer and winter season. The influence of high temperature climates on UIC, measured and estimated urinary iodine excretion will be estimated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 363
• Est. completion date: December 31, 2018
• Est. primary completion date: December 31, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 49 Years

Eligibility

• Female

• Non-pregnant and non-lactating

• General good health, assessed by no reported treatment for chronic disease

• Non-smoking

• No known history of major medical illnesses or thyroid dysfunction as well as gastrointestinal or metabolic disorders and taking no chronic medication

• Residence at the respective study site for 12 months or longer and no plans of moving away during the study year.

• No use of iodine containing dietary supplements during the last 6 months

• No use of X-ray / CT contrast agent or iodine containing medication within the last year

• No use of iodine containing disinfectants during the last 6 months

• Participants should be between 18 and 49 years at date of enrollment

Related Conditions & MeSH terms

• Iodine Deficiency

Intervention

Other:
• Climate
Hot and temperate climate

Locations

Country	Name	City	State
South Africa	Centre of Excellence for Nutrition, Faculty of Health Science, North West University	Potchefstroom
Tanzania	Ministry of Health, Community Development Gender, Elderly and Children	Dar es Salaam

Sponsors (3)

Lead Sponsor	Collaborator
Swiss Federal Institute of Technology	Ministry of Health, Tanzania, North-West University, South Africa

Countries where clinical trial is conducted

South Africa,  Tanzania, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Urinary iodine concentration	Measured in spot urine samples	6 months
Other	Urinary iodine excretion	Measured in spot urine samples	6 months
Primary	Urinary iodine concentration	Measured in 24h urine collections	6 months
Secondary	Urinary iodine excretion	Measured in 24 h urine collections	6 months