Morality Clinical Trial
Official title:
Clinical and Prognostic Comparisons Between Invasive Pulmonary Aspergillosis With or Without Invasive Tracheobronchitis During Severe Influenza: a Retrospective Multicenter Cohort Study.
Invasive tracheobronchial aspergillosis (ITBA) is an uncommon, but severe clinical form of Invasive Pulmonary Aspergillosis (IPA) in which the fungal infection is entirely or predominantly confined to the tracheobronchial tree. In view of the limited data concerning critically ill patients admitted to the intensive care unit (ICU) with severe influenza associated with ITBA, the investigators decided to evaluate the differences between the clinical presentations of two invasive infections: ITBA and IPA without tracheobronchial involvement (No ITBA).
Invasive pulmonary aspergillosis (IPA) is a well-known complication in severely
immunocompromised hosts patients. Recent evidence has identified others populations at risk
for IPA, including those with chronic obstructive pulmonary disease (COPD) and advanced
cirrhosis patients in intensive care units (ICUs). Moreover, Recently influenza has been
identified as a new independent risk factor for IPA and IPA was described as an early
complication of influenza. IPA groups different clinical presentations: the classical
angio-invasive, the broncho-invasive form and the invasive tracheobronchitis aspergillosis
form (ITBA).
ITBA is an infrequent clinical form of IPA with often a fatal outcome, in which Aspergillus
infection involves entirely or predominantly the tracheobronchial tree. Early diagnosis of
ITBA is based on bronchoscopy examination. Severe influenza is a life-threatening condition
where IPA has been repeatedly reported. Little is known on severe influenza infection
complicated with IPA and still less with ITBA. Current data on ITBA in critically ill
patients hospitalized for severe influenza infection has only been described in single case
reports. Because ITBA has been associated with a poorer prognostic than other forms of IPA,
this retrospective study aimed to analyze diagnostic and prognostic differences between ITBA
and IPA without tracheobronchial lesions, in critically ill patients with influenza infection
hospitalized in ICU.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03079726 -
Use of Device Data to Predict Frailty in Individuals
|
||
| Not yet recruiting |
NCT05447611 -
Role of Empathy in Curative Treatment Outcomes of Non-metastatic Colorectal Cancer.
|
||
| Completed |
NCT05268419 -
Efficacy and Safety of Ethanol Inhalation on COVID-19 Treatment (a Clinical Trial Study)
|
Phase 3 | |
| Completed |
NCT05042804 -
Perioperative Outcome Risk Assessment With Computer Learning Enhancement
|
N/A | |
| Recruiting |
NCT03628313 -
Valvular Aortic Stenosis Prognosis Study
|
||
| Completed |
NCT05527678 -
5 Years Quality of Life and Early Mobilization in ICU
|
||
| Recruiting |
NCT05088109 -
Shock Indices Use for Early Mortality From Septic Shock
|
||
| Recruiting |
NCT05073991 -
Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
|
||
| Completed |
NCT05844410 -
Evaluation of Corticosteroids Use and Clinical Outcomes in Hospitalized COVID-19 Patients: A Retrospective Study
|
||
| Recruiting |
NCT05585593 -
Registry for Hypoparathyroidism Wuerzburg
|
||
| Recruiting |
NCT03834246 -
Smoke Inhalation Injury in Patients Admitted to Intensive Care
|
||
| Completed |
NCT03919032 -
Bacterial Infections in Patients With Cirrhosis in Argentina: Clinical and Microbiological Characteristics
|
||
| Completed |
NCT05116670 -
Comparison of Care Practices, Mortality and Morbidity of Very Preterm Infants Between Two Tertiary Centers in Northwest and South of China
|
||
| Withdrawn |
NCT04531839 -
Improving Outcome of Very Preterm Infants Using Collaborative Quality Improvement
|
N/A | |
| Recruiting |
NCT04685278 -
Anticardiolipin Autoantibodies and Mortality in Septic Patients
|
||
| Not yet recruiting |
NCT03665987 -
The Effect of Preoperative Assessment Clinic on Prognosis and Economic Results of Patients With Coexisting Disease.
|
||
| Completed |
NCT04049565 -
CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients
|
||
| Completed |
NCT04971278 -
Evaluating the Impact of a Supportive Care Program
|
||
| Recruiting |
NCT06087315 -
Evaluation of a Multi-country Medical Oxygen Program
|
||
| Completed |
NCT03344627 -
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients
|
N/A |