Clinical Trials Logo
  1. Home
  2. Invasive Fungal Infections
  3. NCT04533087

ImPACt on Invasive Fungal Infections by Immune Checkpoint Inhibition — PACIFIC  

Invasive Fungal Infections Clinical Trial

Official title:
ImPACt on Invasive Fungal Infections by Immune Checkpoint Inhibition

Clinical Trial Summary

This observational study aims to compare immune checkpoint expression in blood samples from patients with invasive fungal infections (IFI) against healthy controls.

Clinical Trial Description

Participating sites will screen patients with invasive aspergillosis for eligibility. The investigators will enroll patients with aspergillosis and healthy controls. Patients will be informed by study personnel. Samples for imune phenotyping will be obtained within 7 days after diagnosis of IFI. A bronchoalveolar lavage (BAL) biopsy is taken at initial diagnostic bronchoscopy or other biopsy during surgical debridement whenever applicable and feasible. The following data items will be collected: Patient characteristics, details on invasive fungal infection (IFI), underlying disease, outcome after 90 days (response, remission, progress, death). All collected data will be interpreted at the end of the study. All patients must agree to participate and sign the informed consent form. The primary objective is to compare immune checkpoint expression in blood samples from patients with IFI against healthy controls. Exploratively, lymphocytic immune phenotypes in BAL or other biopsy samples from patients with IFI will be assessed. Further, cytotoxic T cell responses in blood samples from patients with IFI shall be investigated and the level of immune checkpoint expression correlated with mortality. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04533087
Study type Observational
Source University of Cologne
Contact
Status Completed
Phase
Start date January 1, 2017
Completion date October 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT05749380 - Pharmacokinetics and Safety of AmBisome and DKF-5122 Phase 1
Not yet recruiting NCT02527928 - Cost-Effectiveness of Amphotericin B N/A
Completed NCT02851680 - Interest of ß 1-3 D Glucan Assays in Screening for the Onset of Invasive Aspergillosis in Neutropenic Patients With Acute Leukaemia. N/A
Completed NCT03572049 - Endemic Mycoses Treatment With SUBA-itraconazole vs Itraconazole Phase 2/Phase 3
Suspended NCT05534529 - Rezafungin Paediatric PK Study in Paediatric Subjects From Birth to <18 Years of Age Phase 1
Completed NCT04024995 - Revision of Antifungal Strategies Definitions for Invasive Fungal Infections in Hematological Malignancies
Completed NCT00745992 - Voriconazole Blood Level and Liver Metabolizing Enzyme in Taiwanese Patients
Completed NCT06413056 - Micafungin Versus Amphotercine B in Treatment of Invasive Fungal Infection Phase 4
Recruiting NCT05130723 - Pharmacokinetics of Fluconazole in Children (2-18 Years)
Recruiting NCT04157465 - Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients N/A
Completed NCT04122560 - Fluconazole Pharmacokinetics, Including Bioavailability, in Obese Subjects After an Intravenous and Oral Administration Phase 4
Completed NCT03262584 - Evaluation of NGS for Detection and Follow-up of Fungal Pathogens in Immunocompromised Pediatric Patients
Completed NCT02678598 - A Retrospective Study Evaluating the Efficacy and Safety of Micafungin Sodium in the Treatment of Invasive Fungal Infections N/A
Completed NCT05491733 - A Bioequivalence Study of APX001 High-load and Low-load Tablets Phase 1
Not yet recruiting NCT06220370 - PATH Study: People With Injecting Related Infections: Assessing Treatment Outcomes for Those Who Are Hospitalised.
Completed NCT04777058 - Pharmacokinetics of Isavuconazole in Patients in the Intensive Care Unit
Recruiting NCT03583164 - Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options Phase 2
Completed NCT03174457 - Non-interventional Study for Prevention and Treatment of Fungal Infections in Paediatric Patients in Asia/Oceania - ERADICATE Study
Completed NCT00750737 - Oral Posaconazole Three Times Per Day vs Weekly High Dose Amphotericin B Lipid Complex (ABLC) Phase 3
Not yet recruiting NCT06346951 - Survey on the Current Status of IFD Diagnosis and Treatment by Intensive Care Physicians in Sichuan Province (IFS)