Invasive Fungal Infection Clinical Trial
Official title:
The Correlation of Voriconazole Trough Plasma Levels With Genetic Polymorphism, Efficacy, and Safety Outcomes in Hematologic Malignancy Patients With Invasive Pulmonary Aspergillosis
Multiple factors are associated with a large variability in voriconazole exposure following
standard dose administration, such as non-linear saturable pharmacokinetics, drug-drug
interactions, liver disease, patient age, and genetic polymorphism of the metabolic enzymes.
Voriconazole is extensively metabolized by the human hepatic enzymes, primarily mediated by
CYP2C19. The polymorphisms account for a relatively large portion of inter-individual
variance observed in voriconazole plasma concentrations.
However, there are limited data on the relationships between voriconazole blood levels and
clinical outcomes or safety in Asian populations.
The purpose of this study is to investigate the relationships of voriconazole blood levels
with genetic polymorphism, safety, and clinical outcomes in immunocompromised patients with
invasive pulmonary aspergillosis.
The investigators are trying to establish that routine clinical practice for voriconazole
therapeutic drug monitoring can improve the efficacy and safety outcomes.
In Korean patients with hematologic malignancy, the investigators also want to propose the
optimal dosing guideline of voriconazole with different genetic polymorphisms.
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Observational Model: Case-Only, Time Perspective: Prospective
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