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AKT Inhibitor in Oestrogen Positive Breast Cancer — STAKT  

Invasive Breast Cancer Clinical Trial

Official title:
The Short Term Effects of an AKT Inhibitor (AZD5363) on Biomarkers of the AKT Pathway and Anti-tumour Activity in a Breast Cancer Paired Biopsy Study

Clinical Trial Summary

To compare the effect of four and a half days treatment of a range of doses of AZD5363 on selected markers of the AKT pathway and anti-proliferation compared with placebo in oestrogen receptor positive breast cancers.

To assess the tolerability of four and a half days treatment of AZD5363.

Clinical Trial Description

The principal research questions to be addressed are whether (or not) AZD5363 is "hitting its therapeutic target" sufficiently and to the extent that is required to produce efficacy in pre-clinical experiments.

The primary endpoint markers have been selected to determine this.

Reductions in markers of the AKT pathway and increases in markers of anti-proliferation will characterise the degree of biological activity arising from the inhibition of AKT across a range of doses of AZD5363. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02077569
Study type Interventional
Source University of Nottingham
Contact
Status Completed
Phase Phase 2
Start date January 2014
Completion date February 21, 2017
View Details
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