Intrauterine Growth Restriction Asymmetrical Clinical Trial
Official title:
Effect of L-Arginine on Intrauterine Growth Restriction Fetuses Measured by Birth Weight: Randomized Controlled Trial
Intrauterine growth restriction is an important problem in neonatal care. Intrauterine growth
restriction (IUGR) is defined as a fetal weight below the 10th percentile for gestational
age. One of the main causes of IUGR is placental insufficiency.
Nitric oxide(NO) increases placental blood flow. So,it might be useful to improve IUGR
pregnancy outcome .
The study population includes pregnant women attending Antenatal care clinic of Ain Shams
University Maternity Hospital who first time diagnosed of IUGR at our antenatal care
outpatient clinic either referred for this cause After confirm diagnosis of IUGR and
distributing patient into two groups Patient in first group will receive oral L-arginine
3000mg/day till delivery and Acetylesalicylic acid 75mg once daily.
Patients in second group will receive Acetylesalicylic acid 75mg once daily. then follow up
of both group by:
1. Daily fetal movement counting
2. Day after day CTG
3. Doppler twice weekly
4. Pelvic u/s weekly for:
A) Head circumference, Abdominal circumference, femur length B) Fetal weight C) Liquor
amount: Amniotic Fluid Index Or MeanVertical Pocket
Decision of delivery will be determined when:
A) Fetal distress (non stress CTG) B) Mother starts labour C) Reversed umbilical artery
Doppler.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03038607 -
Aspirin in Asymmetrically Intrauterine Growth
|
Phase 2 |