Intraoperative Pleth Variability Index (PVI) Variability

Intraoperative Monitoring Clinical Trial

Official title: Intraoperative Pleth Variability Index (PVI) Variability

Status Terminated

Clinical Trial Summary

Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG) signal. It is used as a surrogate for intravascular volume status intraoperatively. PVI can have significant amount of baseline variability which appears to oscillate at a very low frequency (5-10 minute cycles). This study aims to investigate the origin of these baseline oscillations.

Clinical Trial Description

PVI is derived from the infrared photoplethysmography signal. Intraoperatively during mechanical ventilation it reflect fluid responsiveness which is a surrogate endpoint of intravascular volume. PVI signal appears to have significant baseline variability which can not be explained by rapid changes in intravascular fluid volume. The baseline PVI changes also appear to oscillate at a very low frequency, much below any previously identified spontaneous vascular oscillations. The aim of this study is to investigate weather the PVI variability originates from changes in the infrared photoplethysmography signal or if they are possibly due to the algorithm calculating PVI. ;

Related Conditions & MeSH terms

• Intraoperative Monitoring

• NCT number: NCT03215238
• Study type: Observational
• Source: University of California, San Francisco
• Status: Terminated
• Start date: October 1, 2017
• Completion date: November 30, 2018