Clinical Trial Details
— Status: Terminated
Administrative data
NCT number |
NCT03215238 |
Other study ID # |
PT1701 |
Secondary ID |
|
Status |
Terminated |
Phase |
|
First received |
|
Last updated |
|
Start date |
October 1, 2017 |
Est. completion date |
November 30, 2018 |
Study information
Verified date |
October 2020 |
Source |
University of California, San Francisco |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG)
signal. It is used as a surrogate for intravascular volume status intraoperatively. PVI can
have significant amount of baseline variability which appears to oscillate at a very low
frequency (5-10 minute cycles). This study aims to investigate the origin of these baseline
oscillations.
Description:
PVI is derived from the infrared photoplethysmography signal. Intraoperatively during
mechanical ventilation it reflect fluid responsiveness which is a surrogate endpoint of
intravascular volume.
PVI signal appears to have significant baseline variability which can not be explained by
rapid changes in intravascular fluid volume. The baseline PVI changes also appear to
oscillate at a very low frequency, much below any previously identified spontaneous vascular
oscillations.
The aim of this study is to investigate weather the PVI variability originates from changes
in the infrared photoplethysmography signal or if they are possibly due to the algorithm
calculating PVI.