Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth

Intraoperative Analgesia Clinical Trial

Official title:

Impact of Preemptive Intravenous Ibuprofen on Intraoperative Analgesia in Third Molar Teeth

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03170726
• Other study ID #: ERZINCAN UNIVERSITY 9
• Status: Active, not recruiting
• Phase: N/A
• First received: May 20, 2017
• Last updated: May 26, 2017
• Start date: May 15, 2017
• Est. completion date: November 15, 2017

Study information

• Verified date: May 2017
• Source: Erzincan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study was planned to evaluate the analgesic efficacy of preemptive intravenous (iv) ibuprofen on pain occurring during and after the mandibular third molar surgeon

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 60
• Est. completion date: November 15, 2017
• Est. primary completion date: October 30, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 35 Years

Eligibility

Inclusion Criteria:

• Patients who are to be elected third molar tooth extraction

• Patients between the ages of 20-35

• Patients who are symptomatic

• Third molar tooth angular or horizontal settled patients

Exclusion Criteria:

• Patients who refuse to participate in the study

• Patients under 20 years old, over 35 years old

• Patients who are allergic to known non-steroidal anti-inflammatory drugs

• Pregnant patients

• Patients with severe liver failure,

• patients with severe renal insufficiency

Related Conditions & MeSH terms

• Intraoperative Analgesia
• Preemptive Intravenous Ibuprofen

Intervention

Drug:
• arveles
Intraoperative and postoperative pain values between these three groups will be compared.
• intrafen 800 mg
ibuprofen 800 mg in normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

Other:
• plasebos
normal saline 150 cc before operation will be given in 30 minutes. Intraoperative and postoperative pain values between these three groups will be compared.

Locations

Country	Name	City	State
Turkey	Erzincan University	Erzincan

Sponsors (1)

Lead Sponsor	Collaborator
Erzincan University

Country where clinical trial is conducted

Turkey, 

References & Publications (5)

Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anaesthesiol. 2009 Oct;22(5):588-93. doi: 10.1097/ACO.0b013e328330373a. Review. — View Citation

Hariharan S, Moseley H, Kumar A, Raju S. The effect of preemptive analgesia in postoperative pain relief--a prospective double-blind randomized study. Pain Med. 2009 Jan;10(1):49-53. doi: 10.1111/j.1526-4637.2008.00547.x. — View Citation

Jerjes W, El-Maaytah M, Swinson B, Banu B, Upile T, D'Sa S, Al-Khawalde M, Chaib B, Hopper C. Experience versus complication rate in third molar surgery. Head Face Med. 2006 May 25;2:14. — View Citation

Oscier CD, Milner QJ. Peri-operative use of paracetamol. Anaesthesia. 2009 Jan;64(1):65-72. doi: 10.1111/j.1365-2044.2008.05674.x. Review. — View Citation

Trampitsch E, Pipam W, Moertl M, Sadjak A, Dorn C, Sittl R, Likar R. [Preemptive randomized, double-blind study with lornoxicam in gynecological surgery]. Schmerz. 2003 Jan;17(1):4-10. German. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	intraoperative pain as assessed by visual analogue scale	Assessment of Preemptive intravenous ibuprofen on intraoperative analgesic efficacy in 3. molar tooth extraction	5 month
Secondary	postoperative pain as assessed by visual analogue scale	postoperative analgesic contribution of preemptively administered intravenous ibuprofen.	5 month