Intraocular Pressure Clinical Trial
Official title:
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular
Verified date | July 2021 |
Source | Siriraj Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG). Setting: Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Study design: Prospective interventional case series Methods: PRP and IVA (2 mg/0.05 ml) injection were given, and TMC was performed within 2 weeks after IVA. Additional PRP, laser suture lysis, subconjunctival 5-fluorouracil injection, and bleb needling were performed after TMC if indicated. Best-collected visual acuity (BCVA), intraocular pressure (IOP), surgical complications, and number of anti-glaucoma medications were collected.
Status | Completed |
Enrollment | 5 |
Est. completion date | March 31, 2021 |
Est. primary completion date | March 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Consecutive patients with neovascular glaucoma who presented at the Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during November 2018 to October 2019. - Aged more than 18 year-old Exclusion Criteria: - Patients who received any anti-vascular endothelial growth factor treatment before participation |
Country | Name | City | State |
---|---|---|---|
Thailand | Naris Kitnarong | Bangkoknoi | Bangkok |
Lead Sponsor | Collaborator |
---|---|
Siriraj Hospital |
Thailand,
Kitnarong N, Chindasub P, Metheetrairut A. Surgical outcome of intravitreal bevacizumab and filtration surgery in neovascular glaucoma. Adv Ther. 2008 May;25(5):438-43. doi: 10.1007/s12325-008-0047-5. — View Citation
Kitnarong N, Sriyakul C, Chinwattanakul S. A Prospective Study to Evaluate Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma. Ophthalmol Ther. 2015 Jun;4(1):33-41. doi: 10.1007/s40123-015-0033-3. Epub 2015 Mar 27 — View Citation
Kobayashi S, Inoue M, Yamane S, Sakamaki K, Arakawa A, Kadonosono K. Long-term Outcomes After Preoperative Intravitreal Injection of Bevacizumab Before Trabeculectomy for Neovascular Glaucoma. J Glaucoma. 2016 Mar;25(3):281-4. doi: 10.1097/IJG.00000000000 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on day 1st | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on day 7th | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 3rd | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 6th | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 12th | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 18th | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 24th | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 30th | |
Primary | Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 36th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on day 1st | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on day 7th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 3rd | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 6th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 12th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 18th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 24th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 30th | |
Secondary | Visual acuity | Visual acuity of the studied eye | Post-operative on month 36th | |
Secondary | Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month12th | |
Secondary | Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month 24th | |
Secondary | Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month 36th |
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