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Clinical Trial Summary

The objective of this study is to evaluate the efficacy and safety of cryoablation combined with anti-pd-1 antibody in patients with advanced hepatocellular carcinoma after progression on first line systemic therapy.


Clinical Trial Description

Recent studies have suggested that local destruction of tumor tissue by cryoablation induced activation and maturation of dendritic cells and tumor-specific T cells by cross-presentation of tumor antigens. While pd-1 blocking antibody interferes with PD-1 mediated T-cell regulatory signaling. Therefore, the objective of this study is to evaluate the efficacy and safety of cryoablation combined with anti-pd-1 antibody in patients in advanced intrahepatic cholangiocarcinoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04299581
Study type Interventional
Source Fudan University
Contact Peng Wang, MD
Phone 86-21-64175590
Email wangp413@163.com
Status Recruiting
Phase Phase 2
Start date July 7, 2020
Completion date May 10, 2024

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