Second Line Therapy for Advanced Intrahepatic Cholangiocarcinoma

Status Not yet recruiting

Clinical Trial Summary

This is a prospective, Two-arm, comparative, randomized, controlled phase II trial, to explore the efficacy and safety of Regorafenib and HAIC vs. FOLFOX as Second Line Therapy for Advanced Intrahepatic Cholangiocarcinoma.

Clinical Trial Description

Currently, complete surgical resection represents the only potentially curative treatment option for cholangiocarcinoma (CCA, including intrahepatic, hilar and distal CCA) and gallbladder carcinoma (GBCA). However,only less than 25% of patients are resectable at diagnosis and, even in this subset of patients, relapse rate is high. Cisplatin and gemcitabine combination was identified as the standard first-line chemotherapy, yielding a median progression free survival (PFS) and median OS of 8.5 and 11.7 months, respectively. FOLFOX was the standard second-line chemotherapy. But the benefit of FOLFOX was limited. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05535647
Study type	Interventional
Source	Tianjin Medical University Cancer Institute and Hospital
Contact
Status	Not yet recruiting
Phase	Phase 2
Start date	September 25, 2022
Completion date	September 25, 2025

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See also
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