Mechanisms and Treatment of Intradialytic Hypertension — MATCH

Intradialytic Hypertension Clinical Trial

Official title:
Blood Pressure, Endothelial Cell Dysfunction, and Outcomes in Dialysis Patients

Status Completed

Clinical Trial Summary

1. To determine in a cross sectional case-controlled cohort study of 50 hemodialysis patients if blood pressure elevations with hemodialysis are associated with decreased endothelial cell function (measured by brachial artery flow mediated dilation and endothelial progenitor cell number), both of which are novel mechanistic markers in the causal pathway for detrimental cardiovascular outcomes; and 2. To determine if lowering blood pressure with carvedilol in 25 ESRD subjects with blood pressure elevations with hemodialysis can improve endothelial cell dysfunction as a surrogate mechanistic marker for improving cardiovascular outcomes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00827775
Study type	Interventional
Source	University of Texas Southwestern Medical Center
Contact
Status	Completed
Phase	Phase 4
Start date	June 2009
Completion date	September 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03038165` - Hemodynamic Parameters Changes in the Course of Hemodialysis Sessions in Patients With Intradialytic Hypertension
Completed	`NCT01371890` - Mechanisms and Treatment of Intradialytic Hypertension - Sodium
Completed	`NCT05430438` - Effect of Low Versus Standard Dialysate Sodium on 48h Ambulatory BP in Patients With Intradialytic Hypertension	N/A
Completed	`NCT01862497` - Mechanisms of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension
Completed	`NCT01916668` - A Cross-sectional Study on Intradialytic Hypertension at Four Haemodialysis Units in the Western Cape	N/A